Description

Amyloid β-Protein (6-20) is a defined synthetic peptide fragment corresponding to residues 6 through 20 of the full-length Amyloid Beta (Aβ) protein. This high-purity peptide is a critical research tool for investigating the molecular mechanisms of Alzheimer's disease, particularly the early stages of Aβ aggregation and oligomer formation. It is essential for scientists and institutions in neuroscience research, pharmaceutical R&D, and diagnostic development who require precise and reliable biochemical reagents.

Application

• Biochemical Research: Fundamental studies on the structure, aggregation kinetics, and toxicity of amyloid beta peptides.
• Drug Discovery Screening: Used as a target or reagent in high-throughput assays to identify potential inhibitors of Aβ aggregation for Alzheimer's therapeutics.
• Antibody Development & Epitope Mapping: Serves as a specific antigen for generating and characterizing antibodies targeting the N-terminal region of Aβ.
• Biophysical Studies: Analysis of peptide-membrane interactions, conformational changes, and oligomerization using techniques like NMR, CD spectroscopy, and surface plasmon resonance (SPR).
• Diagnostic Assay Development: Component in the development and calibration of immunoassays (ELISA) for detecting Aβ species in biological samples.
• Neuroscience Model Systems: Application in cell culture and ex vivo models to study the direct effects of Aβ fragments on neuronal health and function.

Basic Information

Product Name	Amyloid β-Protein (6-20)
CAS No.	183745-82-6
Molecular Formula	C73H115N21O23S
Molecular Weight	1686.9 g/mol
Synonyms	Aβ(6-20); Amyloid β-Protein (6-20) fragment; β-Amyloid (6-20); Aβ6-20; H-VFFAEDVGSNKGAIIGLM-OH; Amyloid Beta Peptide (6-20); Alzheimer's Disease Amyloid Peptide Fragment
EINECS	Contact for details

Quality Control

Our Amyloid β-Protein (6-20) is manufactured under stringent conditions to ensure batch-to-batch consistency and high biological activity. Each lot undergoes comprehensive analytical characterization, including HPLC for purity verification and mass spectrometry (MS) for identity confirmation. Certificates of Analysis (COA) detailing purity, peptide content, and analytical data are provided to support your research integrity and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70% (by weight)
Amino Acid Analysis	Within ± 10% of theoretical
Solubility	Soluble in water or dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.