Description

Amyloid β-Protein (1-15) is a synthetic peptide fragment corresponding to the first 15 amino acids of the amyloid-beta protein. This specific sequence is a critical research tool for studying the early aggregation mechanisms and neurotoxic properties associated with Alzheimer's disease pathology. It is essential for scientists and developers in pharmaceutical R&D, diagnostic assay development, and academic neuroscience research who require high-purity, well-characterized peptides for mechanistic studies and screening applications.

Application

• Alzheimer's Disease Research: Fundamental studies on amyloid-beta aggregation kinetics, oligomer formation, and structure-activity relationships.
• Therapeutic Target Screening: Used as a target in high-throughput screening (HTS) assays to identify potential inhibitors of Aβ aggregation.
• Antibody & Diagnostic Development: Serves as a key antigen for the production and characterization of antibodies used in ELISA, Western blot, and other immunoassays for Alzheimer's biomarkers.
• Biophysical Studies: Investigation of peptide-membrane interactions, conformational changes, and the effects of mutations using techniques like NMR, CD spectroscopy, and surface plasmon resonance (SPR).
• Teaching & Reference Standard: A defined standard for educational purposes and for quality control in related bioanalytical workflows.

Basic Information

Product Name	Amyloid β-Protein (1-15)
CAS No.	183745-81-5
Molecular Formula	C75H111N21O26
Molecular Weight	1690.8 g/mol
Synonyms	Aβ(1-15); Amyloid β-Protein (1-15); Amyloid Beta Peptide (1-15); DAEFRHDSGYEVHHQ; β-Amyloid (1-15); ABETA (1-15); Aβ1-15; Amyloid β (1-15) Fragment
EINECS	Contact for details

Quality Control

Our Amyloid β-Protein (1-15) is manufactured under stringent conditions to ensure batch-to-batch consistency and high biological activity. Each lot undergoes comprehensive analytical characterization, including HPLC for purity verification and mass spectrometry (MS) for identity confirmation. We provide full traceability and Certificates of Analysis (COA) detailing purity, peptide content, and analytical data to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to prevent condensation and hydrolysis. Aliquot reconstituted solutions to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Molecular Weight	1690.8 ± 2 Da (by MS)
Solubility	Soluble in water or dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.