Description

(Boc-Tyr1,D-Ala2)-Leu-Enkephalin-Lys CAS NO 183663-89-0 is a synthetic, modified peptide analog of the endogenous opioid peptide Leu-Enkephalin, featuring a Boc (tert-butoxycarbonyl) protecting group on the tyrosine residue and a D-alanine substitution at the second position. This engineered structure is critical for enhancing metabolic stability and receptor selectivity in advanced pharmacological research. It serves as a key intermediate and reference standard for scientists developing novel analgesics and studying opioid receptor mechanisms. This high-purity peptide is essential for pharmaceutical R&D, biochemical assay development, and proteomics research targeting the central nervous system.

Application

• Pharmaceutical Research & Development: As a critical intermediate in the synthesis of novel, non-addictive analgesic drug candidates targeting opioid receptors.
• Biochemical & Neurobiological Studies: Used as a selective ligand to investigate the binding affinity, signaling pathways, and physiological roles of delta (δ) and mu (μ) opioid receptors.
• Reference Standard for Quality Control: Serves as a high-purity analytical standard for HPLC, MS, and NMR to validate the identity and purity of related peptide compounds in GMP/GLP environments.
• Proteomics & Peptide Library Synthesis: A building block for constructing focused peptide libraries to study structure-activity relationships (SAR) and enzyme-substrate interactions.
• Academic & Institutional Research: Fundamental tool for universities and research institutes studying pain modulation, neurochemistry, and peptide hormone analogs.

Basic Information

Item	Details
Product Name	(Boc-Tyr1,D-Ala2)-Leu-Enkephalin-Lys
CAS No.	183663-89-0
Molecular Formula	C41H60N8O11
Molecular Weight	840.97 g/mol
Synonyms	Boc-Tyr-D-Ala-Gly-Phe-Leu-Lys; Nα-Boc-Tyr-D-Ala-Gly-Phe-Leu-Lys; Boc-Tyr-D-Ala-Gly-Phe-Leu-Lys-OH; (tert-Butoxycarbonyl)-Tyr-D-Ala-Gly-Phe-Leu-Lys; Modified Leu-Enkephalin analog; Opioid peptide analog; Boc-YdAGFLK; BOC-Tyr-D-Ala-Gly-Phe-Leu-Lys
EINECS	Contact for details

Quality Control

Our (Boc-Tyr1,D-Ala2)-Leu-Enkephalin-Lys is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA) to ensure structural integrity and batch-to-batch consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, desiccate and keep frozen. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 2.0%
Amino Acid Composition	Conforms to theoretical values (±10%)
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 70.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.