Description

Leptin (22-56), Human is a synthetic peptide fragment corresponding to amino acids 22-56 of the human leptin protein. This high-purity peptide is a critical research tool for studying the structure-activity relationships and signaling mechanisms of leptin, a key hormone in regulating energy balance and metabolism. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on metabolic disorders, obesity research, and endocrinology.

Application

• Biochemical Research: Used as a reference standard and active agent in studies investigating leptin receptor binding and activation pathways.
• Structure-Activity Relationship (SAR) Studies: Essential for mapping the bioactive regions of the full-length leptin hormone to understand its function.
• In Vitro Assay Development: Serves as a key component in developing cell-based assays and screening platforms for metabolic disease targets.
• Antibody Production & Epitope Mapping: Acts as an immunogen or antigen for generating and characterizing leptin-specific antibodies.
• Signal Transduction Research: Employed to elucidate downstream JAK-STAT and other signaling cascades initiated by leptin.
• Peptide Chemistry & Conjugation: Provides a well-defined peptide backbone for chemical modification and conjugate synthesis for advanced research applications.

Basic Information

Product Name	Leptin (22-56), Human
CAS No.	183598-56-3
Molecular Formula	C185H294N52O55S2
Molecular Weight	4179.8 g/mol
Synonyms	Human Leptin Fragment 22-56; Leptin (22-56); OB Peptide (22-56); Leptin 22-56 amide; LEP (22-56), Human; Obesity Protein Fragment 22-56; Recombinant Human Leptin (22-56); [Des-Leu^(21)]Leptin(22-56)
EINECS	Contact for details

Quality Control

Every batch of Leptin (22-56), Human is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We ensure high purity and batch-to-batch consistency through advanced techniques including HPLC and mass spectrometry. A detailed Certificate of Analysis (COA) providing purity, identity, and impurity profiles is supplied with each shipment to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption. For long-term storage, consider under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Amino Acid Analysis	Within ± 10% of theoretical
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPIC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.