Description

Ac-His(1-Trt)-OH is a protected derivative of the amino acid L-Histidine, featuring a trityl (Trt) group on the imidazole side chain. This compound is a critical building block in solid-phase peptide synthesis (SPPS), where it prevents unwanted side reactions and ensures the correct assembly of complex peptide sequences. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors developing therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key protected amino acid for the controlled assembly of histidine-containing peptides.
• Pharmaceutical Research: Synthesis of peptide-based drug candidates, including hormones, enzyme inhibitors, and antimicrobial peptides.
• Bioconjugation: Used in the preparation of peptide-protein conjugates for antibody-drug conjugates (ADCs) or diagnostic probes.
• Biochemical Tool Development: Incorporation into substrates, inhibitors, or affinity tags for enzymatic studies and protein purification.
• Combinatorial Chemistry: A valuable component in libraries for high-throughput screening of bioactive compounds.
• Academic Research: Fundamental studies in peptide chemistry, structure-activity relationships (SAR), and molecular biology.

Basic Information

Product Name	Ac-His(1-Trt)-OH
CAS No.	183498-47-7
Molecular Formula	C31H28N4O3
Molecular Weight	504.58 g/mol
Synonyms	N-α-Acetyl-N-π-trityl-L-histidine; Ac-L-His(Trt)-OH; Acetyl-Nim-trityl-L-histidine; N-Acetyl-N'-tritylhistidine; N-Acetyl-1-trityl-L-histidine; Nα-Acetyl-Nπ-trityl-L-histidine; (2S)-2-Acetamido-3-[1-(trityl)-1H-imidazol-4-yl]propanoic acid
EINECS	Contact for details

Quality Control

Our Ac-His(1-Trt)-OH is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic methods for structural confirmation. We provide Certificates of Analysis (COA) with detailed results for identity, assay, purity, and related substances, ensuring it meets the stringent requirements for advanced research and cGMP-compliant production environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥98.0%
Purity (HPLC)	≥97.0%
Specific Rotation	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.