Description

4-Chloro-6,7-Bis(2-Methoxyethoxy)Quinazoline is a high-purity, advanced pharmaceutical intermediate of significant commercial importance. This compound serves as a critical building block in the synthesis of targeted therapeutic agents, particularly kinase inhibitors. It is essential for research institutions and pharmaceutical manufacturers engaged in the development of novel oncology and anti-inflammatory treatments, where precise chemical structure and reliable purity are paramount for successful outcomes.

Application

• Key Intermediate in Kinase Inhibitor Synthesis: Primarily used in the research and production of small molecule drugs targeting specific tyrosine kinases.
• Oncology Drug Development: A crucial precursor in the manufacturing of investigational and commercial anti-cancer pharmaceuticals.
• Pharmaceutical R&D: Employed in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Active Pharmaceutical Ingredient (API) Manufacturing: Used in controlled synthesis processes to produce complex active drug substances.
• Biochemical Research: Utilized as a tool compound in biochemical assays to study kinase signaling pathways.

Basic Information

Product Name	4-Chloro-6,7-Bis(2-Methoxyethoxy)Quinazoline
CAS No.	183322-18-1
Molecular Formula	C₁₄H₁₇ClN₂O₄
Molecular Weight	312.75 g/mol
Synonyms	4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline; 6,7-Bis(2-methoxyethoxy)-4-chloroquinazoline; 4-Chloro-6,7-di(2-methoxyethoxy)quinazoline; BIBX 1382 dihydrochloride intermediate; EGFR Inhibitor Intermediate; Quinazoline, 4-chloro-6,7-bis(2-methoxyethoxy)-; Tarceva (Erlotinib) Intermediate; CP-358774 Intermediate
EINECS	Contact for details

Quality Control

Our 4-Chloro-6,7-Bis(2-Methoxyethoxy)Quinazoline is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for pharmaceutical applications. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.