Description

Fmoc-p-Carboxy-Phe(Otbu)-Oh is a protected amino acid derivative widely used as a critical building block in solid-phase peptide synthesis (SPPS). This compound matters for its role in enabling the controlled assembly of complex peptides and peptidomimetics, where the Fmoc and tert-butyl ester groups provide orthogonal protection for the α-amino and side-chain carboxyl functionalities. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences industries developing therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the Fmoc/tBu strategy, facilitating the sequential coupling of amino acids to construct target peptide sequences.
• Pharmaceutical Research & Development: Used in the synthesis of peptide-based drug candidates, including hormones, enzyme inhibitors, and receptor agonists/antagonists.
• Bioconjugation & Probe Development: Serves as a precursor for introducing carboxylic acid handles into peptides for subsequent labeling with fluorophores, biotin, or other functional moieties.
• Combinatorial Chemistry & Library Synthesis: Employed in the generation of diverse peptide libraries for high-throughput screening in drug discovery programs.
• Material Science & Biomaterials: Incorporated into peptide amphiphiles or self-assembling peptides for creating functional nanostructures and bioactive surfaces.

Basic Information

Product Name	Fmoc-p-Carboxy-Phe(Otbu)-Oh
CAS No.	183070-44-2
Molecular Formula	C30H31NO7
Molecular Weight	517.57 g/mol
Synonyms	Fmoc-4-(tert-Butoxycarbonyl)-L-phenylalanine; N-(9-Fluorenylmethoxycarbonyl)-4-(tert-butoxycarbonyl)-L-phenylalanine; Fmoc-L-Phe(4-COOtBu)-OH; Fmoc-p-(tert-Butoxycarbonyl)phenylalanine; Nα-Fmoc-Nε-Boc-L-lysine analog (for Phe derivative); Fmoc-Phe(4-Boc)-OH; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3-[4-[(2-methylpropan-2-yl)oxycarbonyl]phenyl]propanoic acid; Boc-Phe(4-COOtBu)-OH precursor
EINECS	Contact for details

Quality Control

Our Fmoc-p-Carboxy-Phe(Otbu)-Oh is produced under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive research and development applications. All materials are accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with cGMP guidelines where required for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Specific Rotation	-15.0° to -20.0° (c=1 in DMF)
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.