Description

(Pro18,Asp21)-Amyloid β-Protein (17-21) is a synthetic peptide fragment derived from the amyloid β-protein sequence, a key area of study in neurodegenerative research. This compound, with CAS number 182912-74-9, serves as a crucial research tool for investigating protein aggregation, misfolding, and the molecular mechanisms underlying conditions such as Alzheimer's disease. It is primarily utilized by academic institutions, pharmaceutical R&D departments, and biotechnology companies focused on neuroscience and therapeutic discovery.

Application

• Neuroscience Research: Fundamental studies on amyloid beta aggregation kinetics, fibril formation, and neurotoxicity.
• Drug Discovery Screening: Used as a target or reference compound in high-throughput assays to identify potential inhibitors of amyloid aggregation.
• Biophysical Studies: Investigation of peptide structure, stability, and interactions using techniques like NMR, CD spectroscopy, and mass spectrometry.
• Antibody & Diagnostic Development: Serves as an antigen for generating and characterizing antibodies specific to modified amyloid beta sequences.
• Model System for Peptide Chemistry: Study of the effects of specific amino acid substitutions (Pro18, Asp21) on peptide properties and behavior.
• Teaching & Reference Standard: Used in advanced university laboratories for practical training in peptide handling and analysis.

Basic Information

Product Name	(Pro18,Asp21)-Amyloid β-Protein (17-21)
CAS No.	182912-74-9
Molecular Formula	C29H41N7O9
Molecular Weight	631.68 g/mol
Synonyms	Amyloid β-Protein (17-21) fragment, Pro18,Asp21-substituted; Aβ(17-21) (Pro18,Asp21); LVProFAD; H-Leu-Val-Pro-Phe-Asp-OH; Amyloid Beta Peptide (17-21) analog; (Pro18,Asp21)-Aβ(17-21); Research peptide 182912-74-9
EINECS	Contact for details

Quality Control

Every batch of (Pro18,Asp21)-Amyloid β-Protein (17-21) is produced and analyzed under strict quality protocols to ensure identity, purity, and consistency for critical research applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity by HPLC, mass spectrometry (MS) confirmation, and amino acid analysis (AAA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Amino Acid Composition	Conforms to theoretical values
Molecular Weight (MS)	631.68 ± 1.0 Da
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 70%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.