Description

Iberiotoxin Trifluoroacetate Salt is a highly selective and potent peptide inhibitor of the large-conductance calcium-activated potassium (BKCa) channel. This specificity makes it an invaluable research tool for studying ion channel physiology and pharmacology. It is primarily used by researchers in neuroscience, cardiovascular biology, and toxicology for electrophysiological studies, target validation, and as a reference standard.

Application

• Neuroscience Research: Used to study the role of BKCa channels in neuronal excitability, neurotransmitter release, and synaptic plasticity.
• Cardiovascular Research: Employed in investigations of vascular tone regulation, smooth muscle contractility, and cardiac electrophysiology.
• Pharmacological Tool: Serves as a selective blocker in patch-clamp experiments and functional assays to characterize BKCa channel activity in various cell types.
• Toxicology Studies: Utilized to understand the mechanisms of toxins that interact with potassium channels and for comparative studies.
• Biochemical Research: Acts as a reference standard in the development and validation of analytical methods for peptide toxins.
• Ion Channel Drug Discovery: Applied in high-throughput screening (HTS) campaigns to identify novel modulators of BKCa channels for therapeutic development.

Basic Information

Product Name	Iberiotoxin Trifluoroacetate Salt
CAS No.	182897-30-9
Molecular Formula	C179H274N52O55S7 • xC2HF3O2
Molecular Weight	~4237.9 g/mol (free base)
Synonyms	Iberiotoxin; IbTX; BgK; Potassium channel blocker ibTX; BK channel blocker; Charybdotoxin homolog; Peptide toxin from *Buthus tamulus*; 37-amino acid peptide toxin; CAS 129203-60-7 (free base)
EINECS	Contact for details

Quality Control

Our Iberiotoxin Trifluoroacetate Salt is produced and handled under strict quality protocols to ensure batch-to-batch consistency and reliability for critical research. Each lot undergoes comprehensive analytical testing, including HPLC for purity assessment and mass spectrometry for identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, peptide content, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, keep under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70% (by weight)
Water Content (KF)	≤ 5%
Trifluoroacetate Content (HPLC)	≤ 10%
Biological Activity	Confirmed by functional assay (IC50 ~ nM range for BKCa channels)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.