Description

3-Quinolinecarboxylic Acid, 1-Cyclopropyl-8-Ethoxy-7-(4-Ethyl-1-Piperazinyl)-6-Fluoro-1,4-Dihydro-4-Oxo- is a high-purity, advanced pharmaceutical intermediate of significant commercial and research importance. This compound is a key synthetic precursor in the development of novel fluoroquinolone antibiotics, valued for its precise molecular architecture which enables targeted pharmacological activity. It is primarily required by pharmaceutical R&D laboratories, fine chemical manufacturers, and contract development and manufacturing organizations (CDMOs) engaged in the synthesis of next-generation antibacterial agents.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of potent fluoroquinolone antibiotic candidates.
• Antibacterial Drug Development: Used in research and development of new antibacterial agents targeting DNA gyrase and topoisomerase IV enzymes.
• Chemical Synthesis Reference Standard: Serves as a high-purity standard for analytical method development, validation, and quality control in API manufacturing.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to optimize the pharmacokinetic and pharmacodynamic profiles of quinolone derivatives.
• Process Chemistry Scale-Up: Utilized in pilot plant and commercial-scale production processes for active pharmaceutical ingredients (APIs).
• Contract Manufacturing: Supplied to CDMOs for the production of clinical trial materials and commercial drug substances under cGMP guidelines.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 1-Cyclopropyl-8-Ethoxy-7-(4-Ethyl-1-Piperazinyl)-6-Fluoro-1,4-Dihydro-4-Oxo-
CAS No.	182868-82-2
Molecular Formula	C21H26FN3O4
Molecular Weight	403.45 g/mol
Synonyms	1-Cyclopropyl-8-ethoxy-7-(4-ethylpiperazin-1-yl)-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid; 1-Cyclopropyl-6-fluoro-8-ethoxy-7-(4-ethyl-1-piperazinyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid; 7-(4-Ethyl-1-piperazinyl)-1-cyclopropyl-6-fluoro-1,4-dihydro-8-ethoxy-4-oxo-3-quinolinecarboxylic Acid; Gatifloxacin Intermediate; AM-1155 Intermediate; GTX Intermediate; Fluoroquinolone Intermediate Q-03
EINECS	Contact for details

Quality Control

Our 3-Quinolinecarboxylic Acid derivative is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure compliance with stringent specifications suitable for pharmaceutical R&D and cGMP manufacturing. Certificates of Analysis (COA) detailing batch-specific results are provided and can be tailored to meet client-specific requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is light-sensitive (store away from light) and may be incompatible with fluoride compounds and strong alkali. Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5% w/w
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.