Description

3-Quinolinecarboxylic Acid, 1-Cyclopropyl-7-(3,5-Dimethyl-1-Piperazinyl)-8-Ethoxy-6-Fluoro-1,4-Dihydro-4-Oxo- is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This compound is a key synthetic precursor in the development of novel fluoroquinolone antibiotics, offering a critical building block for drug discovery and process chemistry. It is primarily utilized by pharmaceutical R&D laboratories, fine chemical manufacturers, and contract development and manufacturing organizations (CDMOs) engaged in the synthesis of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Primary use as a critical building block in the synthesis of next-generation fluoroquinolone antibiotic APIs.
• Drug Discovery & Development: Serves as a core scaffold for medicinal chemistry research, enabling the creation of new chemical entities with potential antibacterial activity.
• Process Chemistry & Scale-Up: Used in route scouting, optimization, and pilot-scale manufacturing of target drug candidates.
• Contract Manufacturing: Supplied to CDMOs for the production of clinical trial materials and commercial API batches under GMP conditions.
• Reference Standard: High-purity grades are suitable for use as analytical reference standards in quality control laboratories.
• Academic Research: Employed in university and institutional research projects focused on antibiotic resistance and novel antibacterial mechanisms.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 1-Cyclopropyl-7-(3,5-Dimethyl-1-Piperazinyl)-8-Ethoxy-6-Fluoro-1,4-Dihydro-4-Oxo-
CAS No.	182868-75-3
Molecular Formula	C21H26FN3O4
Molecular Weight	403.45 g/mol
Synonyms	1-Cyclopropyl-7-(3,5-dimethylpiperazin-1-yl)-8-ethoxy-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; 8-Ethoxy-6-fluoro-1-cyclopropyl-7-(3,5-dimethyl-1-piperazinyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid; Garenoxacin Intermediate; Garenoxacin Quinoline Core; AM-1155 Intermediate; T-3811 Intermediate; BMS-284756 Intermediate; 1-Cyclopropyl-6-fluoro-8-ethoxy-7-(3,5-dimethylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
EINECS	Contact for details

Quality Control

Our 3-Quinolinecarboxylic Acid derivative is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, residual solvent analysis, and identity confirmation via spectroscopic methods. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Production can be aligned with cGMP guidelines for pharmaceutical applications upon request, ensuring traceability and compliance for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.