Description

3-Quinolinecarboxylic Acid, 8-Bromo-1-Cyclopropyl-6-Fluoro-1,4-Dihydro -7-(3-Methyl-1-Piperazinyl)-4-Oxo- is a high-purity, complex heterocyclic compound that serves as a critical advanced pharmaceutical intermediate. Its sophisticated molecular architecture, featuring a quinoline core with bromo, fluoro, cyclopropyl, and methylpiperazinyl substituents, makes it an essential building block for the synthesis of novel active pharmaceutical ingredients (APIs). This compound is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of next-generation antibacterial agents, particularly fluoroquinolone-class antibiotics.

Application

• Pharmaceutical Intermediate: Key synthetic precursor in the research and commercial production of advanced fluoroquinolone antibiotics.
• Antibacterial Drug Discovery: Core scaffold for medicinal chemistry programs targeting DNA gyrase and topoisomerase IV inhibition.
• Chemical Synthesis: Used in multi-step organic synthesis to introduce complex quinoline-based pharmacophores.
• Process Development: Serves as a reference standard and starting material for optimizing API manufacturing routes in pilot and scale-up facilities.
• Biochemical Research: Investigated for its mechanism of action and structure-activity relationships (SAR) in microbiological studies.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 8-Bromo-1-Cyclopropyl-6-Fluoro-1,4-Dihydro -7-(3-Methyl-1-Piperazinyl)-4-Oxo-
CAS No.	182868-35-5
Molecular Formula	C₁₇H₁₇BrFN₃O₃
Molecular Weight	410.24 g/mol
Synonyms	8-Bromo-1-cyclopropyl-6-fluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid; 8-Bromo-1-cyclopropyl-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; BCPF-MP-4-Oxo-QCA; (1-Cyclopropyl-6-fluoro-8-bromo-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid); Fluoroquinolone Intermediate B-182868; 182868-35-5; 8-Bromo-1-cyclopropyl-6-fluoro-7-(3-methyl-1-piperazinyl)-4(1H)-oxoquinoline-3-carboxylic acid
EINECS	Contact for details

Quality Control

Our 3-Quinolinecarboxylic Acid derivative is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent control of residual solvents and heavy metals. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with cGMP guidelines for pharmaceutical intermediates. Specifications can be tailored to meet specific pharmacopeial or client requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability and potency. Keep the container sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.