Description

3-(2-Pyrimidinyl)-1-Piperidinecarboxylic Acid 1,1-Dimethylethyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a piperidine core substituted with a pyrimidine ring and a tert-butyloxycarbonyl (Boc) protecting group. This compound is critical for medicinal chemistry research and development, enabling the synthesis of complex molecules with targeted biological activity. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the production of novel active pharmaceutical ingredients (APIs) and drug candidates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for developing new therapeutic agents.
• Protease Inhibitor Synthesis: Serves as a precursor in the development of protease inhibitors, a major class of antiviral and anticancer drugs.
• Chemical Biology: Employed in the design and synthesis of chemical probes for studying enzyme function and biological pathways.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for client projects.
• Library Synthesis: Used in the generation of diverse compound libraries for high-throughput screening in drug discovery programs.

Basic Information

Product Name	3-(2-Pyrimidinyl)-1-Piperidinecarboxylic Acid 1,1-Dimethylethyl Ester
CAS No.	182416-13-3
Molecular Formula	C14H21N3O2
Molecular Weight	263.34 g/mol
Synonyms	1-Boc-3-(2-pyrimidinyl)piperidine; tert-Butyl 3-(pyrimidin-2-yl)piperidine-1-carboxylate; 3-(2-Pyrimidinyl)-1-piperidinecarboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-3-(2-pyrimidinyl)piperidine; 3-Pyrimidin-2-yl-piperidine-1-carboxylic acid tert-butyl ester; 3-(2-Pyrimidyl)piperidine-1-carboxylic acid tert-butyl ester; 1-N-Boc-3-(2-pyrimidinyl)piperidine
EINECS	Contact for details

Quality Control

Our 3-(2-Pyrimidinyl)-1-Piperidinecarboxylic Acid 1,1-Dimethylethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring the material meets the stringent requirements for pharmaceutical R&D and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.