Description

Piclozotan CAS NO 182415-09-4 is a high-purity, non-peptide chemical compound belonging to the class of selective serotonin 1A (5-HT1A) receptor antagonists. This specificity makes it a valuable research tool for investigating neurological pathways and developing novel therapeutic agents. It is primarily utilized by pharmaceutical R&D departments, academic research institutions, and contract research organizations (CROs) focused on central nervous system (CNS) disorders, depression, and anxiety.

Application

• Pharmaceutical Research & Development: Serves as a critical reference standard and active pharmaceutical ingredient (API) intermediate in the discovery and development of new CNS-targeting drugs.
• Neuroscience Studies: Used as a selective pharmacological tool to study the role of 5-HT1A receptors in animal models of depression, anxiety, and other behavioral disorders.
• Biochemical Assay Development: Employed in the development and validation of high-throughput screening (HTS) assays and receptor binding studies to identify new drug candidates.
• Academic Research: Facilitates fundamental research in universities and institutes exploring serotonin receptor function, signal transduction, and neuropharmacology.
• Metabolism and Pharmacokinetics (DMPK) Studies: Used to investigate the absorption, distribution, metabolism, and excretion (ADME) profiles of related compounds.
• Quality Control & Analytical Testing: Functions as a certified reference material (CRM) for calibrating analytical instruments like HPLC and LC-MS in quality control laboratories.

Basic Information

Product Name	Piclozotan
CAS No.	182415-09-4
Molecular Formula	C20H21ClN2O3
Molecular Weight	372.85 g/mol
Synonyms	U-101,958; U101958; Piclozotan Hydrochloride (salt form); 4-{4-[4-(Chlorophenyl)-1-piperazinyl]butyl}-2,3,4,5-tetrahydro-1,4-benzoxazepin-3-one; 4-[4-[4-(2-Chlorophenyl)piperazin-1-yl]butyl]-1,2,4,5-tetrahydro-3H-3-benzazepin-3-one; 5-HT1A Receptor Antagonist U-101958
EINECS	Contact for details

Quality Control

Our Piclozotan is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. While produced to meet general research-grade standards, specifications can be aligned with specific project requirements for advanced pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.