Description

3-(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino}-3-(3-Trifluoromethyl-Phenyl)-Propanoic Acid is a high-purity, non-natural amino acid derivative primarily used as a critical building block in advanced organic synthesis. This compound is valued for its role in introducing the trifluoromethylphenyl moiety, a key structural feature known to enhance the metabolic stability and binding affinity of target molecules. It is an essential intermediate for research and development chemists in the pharmaceutical and agrochemical industries, particularly in the synthesis of peptide-based therapeutics, enzyme inhibitors, and novel bioactive compounds.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel peptide-based drugs and enzyme inhibitors targeting various diseases.
• Agrochemical Research: Used in the development of advanced pesticides and herbicides, where the trifluoromethyl group can improve biological activity and environmental stability.
• Peptide Synthesis (Fmoc Chemistry): Serves as a protected amino acid derivative in solid-phase peptide synthesis (SPPS) using Fmoc (9-fluorenylmethoxycarbonyl) protection strategies.
• Chemical Biology Probes: Employed in the creation of labeled peptides and molecular probes for studying protein-protein interactions and cellular processes.
• Material Science: Potential monomer or precursor for specialized polymers and advanced organic materials with unique electronic or surface properties.
• Contract Research & Development (CRO/CMO): Supplied to research organizations for custom synthesis and process development projects.

Basic Information

Product Name	3-(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino}-3-(3-Trifluoromethyl-Phenyl)-Propanoic Acid
CAS No.	181953-60-6
Molecular Formula	C25H20F3NO4
Molecular Weight	455.43 g/mol
Synonyms	Fmoc-3-(3-Trifluoromethylphenyl)-β-alanine; Fmoc-3-(3-(Trifluoromethyl)phenyl)-β-alanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(3-trifluoromethylphenyl)-β-alanine; 3-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3-[3-(trifluoromethyl)phenyl]propanoic acid; (R,S)-N-Fmoc-3-(3-trifluoromethylphenyl)-β-alanine; Fmoc-β-homo-TfmPhe-OH; Fmoc-3-(3-CF3-Ph)-β-Ala-OH
EINECS	Contact for details

Quality Control

Our production of 3-(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino}-3-(3-Trifluoromethyl-Phenyl)-Propanoic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity suitable for research and cGMP applications. Each lot is analyzed using advanced techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 98.5%
Single Unknown Impurity	≤ 0.5%
Total Impurities	≤ 1.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.