Description

Fmoc-Tyr(So3H)-Oh is a specialized, sulfonated tyrosine derivative protected with a 9-fluorenylmethoxycarbonyl (Fmoc) group, designed for advanced peptide synthesis. This modified amino acid building block is critical for introducing sulfonate functionality, which can significantly enhance the solubility, stability, and biological activity of synthetic peptides. It is an essential reagent for researchers and manufacturers in pharmaceutical development, proteomics research, and the production of therapeutic peptides and peptidomimetics, where precise chemical modification is required.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated synthesis of peptides containing sulfonated tyrosine residues.
• Pharmaceutical R&D: For developing novel peptide-based drugs where sulfonation modulates receptor binding, bioavailability, or metabolic stability.
• Chemical Biology & Proteomics: Used to create activity-based probes or affinity tags to study protein-protein interactions and post-translational modifications.
• Bioconjugation: Serves as a precursor for creating peptide conjugates with dyes, polymers, or other biomolecules for diagnostic or therapeutic applications.
• Material Science: Incorporation into peptide amphiphiles or self-assembling peptides to create functional biomaterials with enhanced hydrophilic character.

Basic Information

Product Name	Fmoc-Tyr(So3H)-Oh
CAS No.	181952-24-9
Molecular Formula	C24H21NO8S
Molecular Weight	483.49 g/mol
Synonyms	Fmoc-O-sulfo-L-tyrosine; Fmoc-L-tyrosine(O-sulfate); Fmoc-Tyr(OSO3H)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-sulfo-L-tyrosine; N-Fmoc-O-sulfo-L-tyrosine; Fmoc-Tyrosine(SO3H)-OH; (2S)-2-[(9H-Fluoren-9-ylmethoxy)formamido]-3-(4-sulfooxyphenyl)propanoic acid; Fmoc-Sulfotyrosine
EINECS	Contact for details

Quality Control

Our Fmoc-Tyr(So3H)-Oh is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for sensitive research and production applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles as determined by advanced analytical techniques including HPLC, NMR, and mass spectrometry. We support compliance with cGMP and ISO 9001 standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0% (Area %)
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines
Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.