Description

β-Amyloid (10-35), Amide is a synthetic peptide fragment corresponding to a specific region of the amyloid-beta protein. This compound is a critical research tool for studying the aggregation mechanisms, neurotoxicity, and structural biology associated with Alzheimer's disease and other amyloid-related pathologies. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on neuroscience, drug discovery, and diagnostic development.

Application

• Neuroscience Research: Fundamental studies on amyloid-beta peptide aggregation kinetics, fibril formation, and oligomer toxicity.
• Drug Discovery Screening: Serving as a target or substrate in high-throughput assays to identify potential inhibitors of amyloid aggregation.
• Biophysical Studies: Utilization in techniques like NMR, X-ray crystallography, and circular dichroism (CD) to elucidate peptide structure and conformation.
• Antibody & Diagnostic Development: Use as an antigen for the production and characterization of antibodies targeting amyloid-beta, or as a calibrator in immunoassays.
• Cell-based Assays: Investigation of peptide-induced cytotoxicity and cellular pathways in neuronal cell culture models.
• Teaching & Method Development: A standard reagent for training and establishing laboratory protocols in peptide handling and analysis.

Basic Information

Product Name	β-Amyloid (10-35), Amide
CAS No.	181427-66-7
Molecular Formula	C128H203N41O43S
Molecular Weight	2983.3 g/mol
Synonyms	Amyloid β-Protein (10-35) amide; Aβ(10-35)-NH2; β-Amyloid (10-35) peptide amide; Amyloid β-Peptide (10-35) (human) amide; Aβ10-35 amide; Amyloid-β (10-35) fragment amide; H-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-NH2
EINECS	Contact for details

Quality Control

Every batch of β-Amyloid (10-35), Amide is manufactured and analyzed under stringent quality management systems. Our products undergo rigorous purity verification using advanced analytical techniques including HPLC and mass spectrometry to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and peptide content is provided with each shipment to guarantee traceability and reproducibility for your critical research.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. Aliquot reconstituted solutions to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70% (by weight)
Molecular Weight	2983.3 ± 2.0 Da (by MS)
Solubility	Soluble in water or dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.