Description

Fmoc-L-Homocystine CAS NO 181370-86-5 is a high-purity, protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound serves as a critical building block for introducing the homocystine moiety into peptide chains, enabling the study of disulfide bond formation and protein folding. It is primarily utilized by pharmaceutical researchers, biotechnology companies, and academic institutions engaged in the development of novel therapeutic peptides and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected intermediate for the controlled incorporation of homocystine into custom peptide sequences.
• Pharmaceutical Research: Used in the R&D of peptide-based drugs targeting metabolic disorders, cardiovascular diseases, and oncology.
• Bioconjugation & Probe Development: Facilitates the creation of labeled peptides for diagnostic assays and molecular imaging studies.
• Biochemical Studies: Enables research into protein structure, stability, and disulfide bridge engineering.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening of bioactive peptide candidates.
• Academic & Institutional Research: Supports fundamental studies in biochemistry, medicinal chemistry, and molecular biology.

Basic Information

Product Name	Fmoc-L-Homocystine
CAS No.	181370-86-5
Molecular Formula	C38H36N2O8S2
Molecular Weight	712.83 g/mol
Synonyms	N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-homocystine; Fmoc-Hcy-OH; Fmoc-L-Hcy-OH; Fmoc-homocystine; (2R)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-4-[[(4R)-4-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-4-carboxybutyl]disulfanyl]butanoic acid; Nα-Fmoc-L-homocystine; Fmoc-L-HomoCys-OH; Fmoc-L-Hcy
EINECS	Contact for details

Quality Control

Our Fmoc-L-Homocystine is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.