Description

Fmoc-Trp(Boc)-Opfp CAS NO 181311-44-4 is a specialized, protected amino acid derivative designed for use in solid-phase peptide synthesis (SPPS). This compound is critical for the efficient and high-purity assembly of complex peptides, particularly those containing tryptophan residues. It is an essential building block for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences industries developing therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid derivative for the automated, stepwise construction of peptide chains.
• Pharmaceutical R&D: For the synthesis of novel peptide-based drug candidates, including hormones, antibiotics, and enzyme inhibitors.
• Bioconjugation: Used to introduce tryptophan motifs into proteins, antibodies, or other biomolecules for labeling or functionalization.
• Combinatorial Chemistry: A valuable reagent in libraries for high-throughput screening to discover new bioactive compounds.
• Academic Research: Fundamental studies in peptide chemistry, structure-activity relationships (SAR), and molecular biology.
• Production of Custom Peptides: By contract research organizations (CROs) and CDMOs serving the global biopharma sector.

Basic Information

Product Name	Fmoc-Trp(Boc)-Opfp
CAS No.	181311-44-4
Molecular Formula	C₃₆H₂₈F₅N₃O₆
Molecular Weight	693.62 g/mol
Synonyms	Fmoc-Tryptophan(Boc)-OPfp; Fmoc-Trp(Boc)-OPfp ester; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N'-(tert-butoxycarbonyl)-L-tryptophan pentafluorophenyl ester; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(1-((tert-butoxycarbonyl)indol-3-yl)propanoic acid 2,3,4,5,6-pentafluorophenyl ester; Fmoc-L-Trp(Boc)-OPfp; Fmoc-Trp(Boc)-O-Pfp; Fmoc-Trp(Boc)-OPfp active ester
EINECS	Contact for details

Quality Control

Our Fmoc-Trp(Boc)-Opfp is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Specific Rotation	-15.0° to -25.0° (c=1, DMF)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.