Description

(S)-Fmoc-2-Amino-4,4,4-Trifluoro-Butyric Acid is a high-purity, non-natural amino acid derivative designed for advanced peptide synthesis. This compound is a critical building block for introducing the unique physicochemical properties of the trifluoromethyl group into peptide chains, enhancing metabolic stability and lipophilicity. It is primarily utilized by pharmaceutical researchers and fine chemical manufacturers in the development of novel therapeutic peptides and peptidomimetics.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/t-Bu strategy, enabling the controlled incorporation of a trifluoromethylated side chain.
• Peptidomimetic Drug Discovery: Used to synthesize peptide analogs with improved bioavailability, membrane permeability, and resistance to enzymatic degradation.
• Chemical Biology Probes: Serves as a building block for creating labeled or modified peptides to study protein-protein interactions and enzyme mechanisms.
• Agrochemical Research: Employed in the synthesis of bioactive peptide-like compounds for crop protection and pest management.
• Material Science: Facilitates the creation of fluorinated peptides for surface modification and the development of specialized biomaterials.

Basic Information

Product Name	(S)-Fmoc-2-Amino-4,4,4-Trifluoro-Butyric Acid
CAS No.	181128-48-3
Molecular Formula	C19H16F3NO4
Molecular Weight	379.33 g/mol
Synonyms	Fmoc-Tfa-OH; (S)-N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4,4,4-trifluoro-2-aminobutanoic Acid; Fmoc-4,4,4-trifluoro-L-norvaline; Fmoc-L-CF3-norvaline; N-α-Fmoc-4,4,4-trifluoro-L-norvaline; (2S)-2-[(9H-Fluoren-9-ylmethoxy)formamido]-4,4,4-trifluorobutanoic Acid; Fmoc-2-Amino-4,4,4-trifluoro-Butyric Acid
EINECS	Contact for details

Quality Control

Our (S)-Fmoc-2-Amino-4,4,4-Trifluoro-Butyric Acid is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, typically ≥98% (HPLC). Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We support cGMP and ISO compliant documentation for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.