Description

L-Proline, 3-Methyl-, Methyl Ester, trans- (9Ci) is a chiral, non-proteinogenic amino acid derivative, specifically a methylated proline ester. This compound matters as a versatile and high-purity building block for advanced organic synthesis, particularly in the development of pharmaceuticals and bioactive molecules. It is needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for applications in peptide mimetics, drug discovery, and asymmetric synthesis.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel active pharmaceutical ingredients (APIs) and peptide-based drugs.
• Peptidomimetics Research: Used to introduce conformational constraints and modify the biological activity and stability of peptide analogs.
• Asymmetric Catalysis: Serves as a precursor for chiral ligands or catalysts in stereoselective chemical transformations.
• Agrochemical Synthesis: Employed in the research and development of advanced, enantiomerically pure crop protection agents.
• Biochemical Research: Utilized as a probe or standard in metabolic studies and enzyme inhibition assays.
• Fine Chemical Production: Acts as a building block for complex natural products and specialty chemicals requiring high stereochemical purity.

Basic Information

Product Name	L-Proline, 3-Methyl-, Methyl Ester, trans- (9Ci)
CAS No.	180724-68-9
Molecular Formula	C7H13NO2
Molecular Weight	143.18 g/mol
Synonyms	(2S,3S)-3-Methylproline methyl ester; trans-3-Methyl-L-proline methyl ester; Methyl (2S,3S)-3-methylpyrrolidine-2-carboxylate; (2S,3S)-1-Methyl 3-methylpyrrolidine-2-carboxylate; L-3-Methylproline methyl ester; trans-3-Methyl-L-proline methyl ester hydrochloride (salt form); (2S,3S)-3-Methylproline methyl ester hydrochloride
EINECS	Contact for details

Quality Control

Our L-Proline, 3-Methyl-, Methyl Ester, trans- (9Ci) is produced under stringent quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with high-purity standards for research and synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.