Description

Fmoc-Asp(Ompe)-Oh CAS NO 180675-08-5 is a high-purity, protected aspartic acid derivative specifically engineered for solid-phase peptide synthesis (SPPS). This compound is critical for researchers and manufacturers requiring precise control over side-chain functionality during the construction of complex peptides and peptidomimetics. It is an essential building block for pharmaceutical R&D, particularly in the development of therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated, sequential assembly of peptide chains.
• Pharmaceutical Research: Building block for the synthesis of novel therapeutic peptides targeting metabolic disorders, oncology, and infectious diseases.
• Bioconjugation & Linker Chemistry: Utilized to introduce functional handles or specific side-chain modifications for drug-antibody conjugates (ADCs) or labeling studies.
• Combinatorial Chemistry Libraries: Used in the generation of diverse peptide libraries for high-throughput screening and drug discovery.
• Biochemical Research: Synthesis of substrate analogs, enzyme inhibitors, and probes for studying protein-protein interactions and enzymatic mechanisms.
• Material Science: Precursor for designing peptide-based biomaterials, hydrogels, and surface coatings with specific functional properties.

Basic Information

Product Name	Fmoc-Asp(Ompe)-Oh
CAS No.	180675-08-5
Molecular Formula	C₂₄H₂₇NO₇
Molecular Weight	441.48 g/mol
Synonyms	Fmoc-Asp(OMpe)-OH; Fmoc-L-Aspartic Acid 4-Methyl Ester; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-aspartic Acid 4-Methyl Ester; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]butanedioic Acid 4-Methyl Ester; Fmoc-Asp(OMe)-OH (common abbreviation); Fmoc-Asp-Ome; N-Fmoc-L-aspartic Acid β-Methyl Ester; Fmoc-Aspartic Acid 4-Methyl Ester
EINECS	Contact for details

Quality Control

Every batch of Fmoc-Asp(Ompe)-Oh is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, chiral purity, and impurity profiles. Our quality standards are designed to meet the rigorous demands of GMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.