Description

6-Hydroxy-2-[4-(Trifluoromethyl)Phenyl]-4(3H)-Pyrimidinone is a high-purity, heterocyclic organic compound featuring a pyrimidinone core substituted with a trifluoromethylphenyl group. This specific molecular architecture makes it a valuable key intermediate and building block for advanced chemical synthesis, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily sought after by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in creating novel therapeutic and crop protection agents.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-inflammatory agents, and antiviral compounds.
• Agrochemical Research: Used as a building block for developing new-generation herbicides, fungicides, and insecticides, leveraging the biological activity of the pyrimidinone scaffold.
• Material Science: Investigated for the creation of specialty polymers, liquid crystals, and organic electronic materials due to its rigid, aromatic structure and potential for functionalization.
• Chemical Synthesis: Acts as a versatile reagent in organic chemistry for constructing complex heterocyclic systems via condensation and cyclization reactions.
• Biochemical Research: Utilized in biochemical assays and as a reference standard for studying enzyme inhibition or receptor binding activities.

Basic Information

Product Name	6-Hydroxy-2-[4-(Trifluoromethyl)Phenyl]-4(3H)-Pyrimidinone
CAS No.	180606-37-5
Molecular Formula	C11H7F3N2O2
Molecular Weight	256.18 g/mol
Synonyms	2-(4-Trifluoromethylphenyl)-6-hydroxy-4(3H)-pyrimidinone; 6-Hydroxy-2-[4-(trifluoromethyl)phenyl]-4(3H)-pyrimidinone; 4(3H)-Pyrimidinone, 6-hydroxy-2-[4-(trifluoromethyl)phenyl]-; 2-(4-Trifluoromethylphenyl)-6-hydroxypyrimidin-4(3H)-one; 6-Hydroxy-2-(4-trifluoromethylphenyl)pyrimidin-4(3H)-one; 180606-37-5; 6-Hydroxy-2-(α,α,α-trifluoro-p-tolyl)-4(3H)-pyrimidinone
EINECS	Contact for details

Quality Control

Our 6-Hydroxy-2-[4-(Trifluoromethyl)Phenyl]-4(3H)-Pyrimidinone is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.