Description

Fmoc-D-Asn(Trt)-Oh is a protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This high-purity building block is critical for researchers and manufacturers creating complex peptides with precise stereochemistry and side-chain protection. It is primarily used by the pharmaceutical, biotechnology, and academic research sectors for the development of therapeutic peptides, diagnostic agents, and biochemical tools. Its role in enabling the synthesis of challenging peptide sequences makes it a key reagent in modern life sciences.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it serves as a fundamental building block for the sequential assembly of peptides on resin.
• Pharmaceutical Research & Development: Used in the synthesis of peptide-based drug candidates, including potential treatments for metabolic, oncological, and infectious diseases.
• Bioconjugation: Employed to introduce specific D-asparagine residues into peptides for subsequent conjugation with other molecules like dyes, polymers, or drug payloads.
• Combinatorial Chemistry: A key component in libraries for high-throughput screening to discover new bioactive peptides.
• Peptide Antigen Production: Used to synthesize specific peptide sequences for antibody production and immunological studies.
• Academic & Institutional Research: Essential for basic scientific research in biochemistry, structural biology, and medicinal chemistry.

Basic Information

Product Name	Fmoc-D-Asn(Trt)-Oh
CAS No.	180570-71-2
Molecular Formula	C39H34N2O5
Molecular Weight	610.70 g/mol
Synonyms	Fmoc-D-asparagine(trityl)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N'-trityl-D-asparagine; Fmoc-D-Asn(Trt)-OH; Fmoc-D-Asparagine(Trt)-OH; (2R)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3-[(tritylamino)carbonyl]propanoic acid; Nα-Fmoc-Nβ-trityl-D-asparagine
EINECS	Contact for details

Quality Control

Our Fmoc-D-Asn(Trt)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive applications like peptide synthesis. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral analysis to confirm stereochemical integrity. A Certificate of Analysis (COA) detailing identity, purity, and specific impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed in a desiccated environment to maintain stability and purity. For long-term storage, consider storing at 2-8°C under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Optical Rotation	-15.0° to -18.0° (c=1 in DMF)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.