Description

Fmoc-L-Homoleucine CAS NO 180414-94-2 is a protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This high-purity building block is critical for ensuring the fidelity and yield of complex peptide sequences during automated synthesis. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and academic research institutions engaged in the development of therapeutic peptides, peptidomimetics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected amino acid building block for the sequential assembly of custom peptides.
• Pharmaceutical Research: Used in the discovery and development of novel peptide-based therapeutics, including hormones, antibiotics, and enzyme inhibitors.
• Bioconjugation & Probe Development: Serves as a precursor for creating labeled peptides or peptide-drug conjugates for diagnostic and targeting applications.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to identify bioactive peptide leads.
• Academic & Biochemical Research: Fundamental reagent for studying protein-protein interactions, enzyme substrates, and structure-activity relationships (SAR).
• Production of Non-Natural Amino Acid Derivatives: Acts as a chiral starting material for the synthesis of more complex, specialized amino acid analogs.

Basic Information

Product Name	Fmoc-L-Homoleucine
CAS No.	180414-94-2
Molecular Formula	C₂₂H₂₅NO₄
Molecular Weight	367.44 g/mol
Synonyms	N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-homoleucine; Fmoc-HomoLeu-OH; (2S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-4-methylhexanoic acid; N-Fmoc-L-homoleucine; Fmoc-L-2-amino-4-methylhexanoic acid; Fmoc-L-2-amino-4-methylcaproic acid; N-α-Fmoc-L-homoleucine
EINECS	Contact for details

Quality Control

Our Fmoc-L-Homoleucine is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, typically meeting standards suitable for advanced research and pharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with cGMP and ISO guidelines for critical raw materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a desiccated environment to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.5%
Optical Rotation [α]²⁰D	Contact for details
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Meets ICH guidelines
Single Impurity (HPLC)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.