Description

Tezosentan Disodium is a potent, competitive dual endothelin receptor antagonist (ERA) used in advanced pharmacological research. This compound is critical for investigating the role of endothelin in cardiovascular pathophysiology, particularly pulmonary arterial hypertension (PAH) and heart failure. It is an essential research-grade chemical for pharmaceutical R&D laboratories, academic institutions, and biotechnology companies focused on cardiovascular drug discovery and mechanism-of-action studies.

Application

• Cardiovascular Research: Primary tool for studying endothelin-1 (ET-1) signaling pathways in models of pulmonary arterial hypertension (PAH), systemic hypertension, and congestive heart failure.
• Pharmacological Profiling: Used in in vitro and in vivo assays to evaluate the efficacy and selectivity of novel endothelin receptor antagonists.
• Preclinical Development: Serves as a key reference standard and active pharmaceutical ingredient (API) in the early-stage development of new therapeutic agents targeting the endothelin system.
• Academic & Institutional Studies: Facilitates basic science research into vascular tone regulation, fibrosis, and endothelial dysfunction across various disease models.
• Biomarker Investigation: Supports studies correlating endothelin receptor blockade with clinical biomarkers in experimental settings.

Basic Information

Product Name	Tezosentan Disodium
CAS No.	180384-58-1
Molecular Formula	C19H18N6Na2O11S2
Molecular Weight	624.48 g/mol
Synonyms	Tezosentan Disodium Salt; Ro 61-0612 disodium; (2R,3S,4S)-4-(1,3-Benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid disodium salt; 5-Isopropyl-pyrazine-2-carboxylic acid [2-(1H-tetrazol-5-yl)-hexahydro-cyclopenta[c]pyrrol-5-yl]-amide disodium salt; Dual Endothelin Receptor Antagonist; ERA
EINECS	Contact for details

Quality Control

Our Tezosentan Disodium is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency suitable for research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry guidelines for research chemicals to ensure product integrity and reliable performance in your experimental systems.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.