Description

Tezosentan is a potent, competitive dual endothelin receptor antagonist (ERA) targeting both ETA and ETB receptors. This compound is a critical research tool and pharmaceutical intermediate for investigating and developing treatments for cardiovascular and pulmonary conditions, particularly pulmonary arterial hypertension (PAH). It is essential for pharmaceutical R&D laboratories, academic research institutions, and manufacturers of active pharmaceutical ingredients (APIs) focused on endothelin pathway modulation.

Application

• Pharmaceutical Research & Development: A key reference standard and intermediate in the discovery and synthesis of novel endothelin receptor antagonists.
• Cardiovascular Disease Studies: Used in preclinical and clinical research to investigate its effects on conditions like pulmonary arterial hypertension (PAH), chronic heart failure, and systemic hypertension.
• Mechanistic Biological Studies: Employed as a selective pharmacological tool to block endothelin-1 (ET-1) signaling in vitro and in vivo, helping to elucidate the role of the endothelin system in various pathologies.
• API Manufacturing: Serves as a high-purity building block or intermediate in the synthesis of more complex therapeutic agents targeting endothelin receptors.
• Biochemical Assay Development: Utilized to validate and calibrate assays designed to screen for ERA activity or to measure endothelin levels.

Basic Information

Product Name	Tezosentan
CAS No.	180384-57-0
Molecular Formula	C31H32N6O8S
Molecular Weight	648.69 g/mol
Synonyms	Ro 61-0612; Tezosentan disodium; 5-Isopropyl-pyridine-2-sulfonic acid [6-(2-hydroxy-ethoxy)-5-(2-methoxy-phenoxy)-2-(2H-1,2,3,4-tetrazol-5-yl)-pyrimidin-4-yl]-amide; 4'-[(6,7-Dimethoxy-4-quinazolinyl)oxy]phenyl]amino]-6-methoxy-7-[3-(1-pyrrolidinyl)propoxy]quinazoline (common mis-association corrected); Dual Endothelin Receptor Antagonist
EINECS	Contact for details

Quality Control

Our Tezosentan is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and MS, and stringent control of residual solvents and impurities. Certificates of Analysis (COA) detailing all specifications and test results are provided to ensure compliance with research and pharmaceutical-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	≤20 ppm
Assay (on dried basis)	97.0% - 103.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.