Description

Gatifloxacin Sesquihydrate CAS NO 180200-66-2 is a high-purity pharmaceutical active ingredient belonging to the fourth-generation fluoroquinolone class of antibiotics. It is valued for its broad-spectrum antibacterial activity against both Gram-positive and Gram-negative pathogens. This compound is essential for pharmaceutical manufacturers and research institutions developing advanced antibiotic formulations and conducting microbiological studies.

Application

• Active Pharmaceutical Ingredient (API) in the manufacture of antibiotic drugs.
• Pharmaceutical Intermediates for synthesizing more complex fluoroquinolone derivatives.
• Research & Development of new antibacterial agents and combination therapies.
• Microbiological Studies as a reference standard for susceptibility testing.
• Veterinary Medicine for developing treatments for bacterial infections in animals.
• Ophthalmic Solutions formulation for treating bacterial conjunctivitis and other eye infections.

Basic Information

Product Name	Gatifloxacin Sesquihydrate
CAS No.	180200-66-2
Molecular Formula	C19H22FN3O4 • 1.5 H2O
Molecular Weight	402.41 g/mol (Anhydrous basis)
Synonyms	Gatifloxacin Hemihydrate; (±)-1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid Sesquihydrate; AM-1155; BMS-206584; Gatifloxacine Sesquihydrate; Tequin; Zymar; GTX
EINECS	Contact for details

Quality Control

Our Gatifloxacin Sesquihydrate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. We provide Certificates of Analysis (COA) with detailed results for parameters including assay, related substances, residual solvents, and microbial limits, supporting compliance with ICH guidelines and customer-specific requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Conforms to standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	5.0% - 7.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	≤ 20 ppm
Sulfated Ash	≤ 0.1%
Microbial Enumeration	Complies with Ph. Eur. 2.6.12/2.6.13

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.