Description

n-(2-Maleimidoethyl)Diethylenetriaminepentaacetic Acid, Monoamide is a heterobifunctional chelating agent that combines a maleimide group for thiol-specific conjugation with a DTPA-derived moiety for high-affinity metal ion binding. This compound is critical for creating stable, site-specific bioconjugates for diagnostic and therapeutic applications. It is primarily utilized by researchers and manufacturers in the fields of radiopharmaceuticals, targeted drug delivery, and advanced in vitro diagnostics.

Application

• Radiopharmaceutical Chelation: Conjugation to antibodies, peptides, or other targeting vectors for labeling with diagnostic (e.g., 111In, 99mTc) or therapeutic (e.g., 90Y, 177Lu) radioisotopes.
• Targeted Drug Delivery Systems: Site-specific attachment of cytotoxic agents or imaging probes to monoclonal antibodies or nanocarriers.
• In Vitro Diagnostic (IVD) Assays: Development of enzyme or fluorescent metal-chelate based immunoassays and biosensors.
• Magnetic Resonance Imaging (MRI) Contrast Agents: Synthesis of targeted contrast agents by conjugating the chelator to a targeting molecule and complexing with gadolinium (Gd3+).
• Protein and Biomolecule Immobilization: Thiol-directed covalent immobilization of proteins onto surfaces or particles pre-functionalized with metal ions.
• Research Tool in Chemical Biology: Used for studying protein-protein interactions, cell surface labeling, and intracellular tracking via metal-based detection.

Basic Information

Product Name	n-(2-Maleimidoethyl)Diethylenetriaminepentaacetic Acid, Monoamide
CAS No.	180152-82-3
Molecular Formula	C24H35N5O12
Molecular Weight	585.56 g/mol
Synonyms	Maleimidoethyl-DTPA; Maleimide-DTPA; 2-Maleimidoethyl DTPA; DTPA-Maleimide; DTPA-MAL; N-(2-Maleimidoethyl)-DTPA monoamide; 2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-[2-[bis[2-[bis(carboxymethyl)amino]ethyl]amino]ethyl]acetamide; 1-[2-[[2-[Bis[2-[bis(carboxymethyl)amino]ethyl]amino]ethyl]amino]-2-oxoethyl]-1H-pyrrole-2,5-dione
EINECS	Contact for details

Quality Control

Our n-(2-Maleimidoethyl)Diethylenetriaminepentaacetic Acid, Monoamide is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistent performance for sensitive bioconjugation applications. Certificates of Analysis (COA) detailing purity, identity, and functional group integrity are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Functional Group Integrity	≥ 90% (Maleimide & Chelator)
Solubility	Soluble in water, DMSO, DMF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.