Description

H-Tyr-Pro-Ile-Lys-Pro-Glu-Ala-Pro-Gly-Glu-Asp-Ala-Ser-Pro-Glu-Glu-Leu-Asn-Arg-Tyr-Tyr-Ala-Ser-Leu-Arg-His-Tyr-Leu-Asn-Leu-Val-Thr-Arg-Pro-Arg-Tyr-Nh2 is a synthetic peptide sequence, also known as a fragment of the parathyroid hormone-related protein (PTHrP). This compound is of significant interest for biomedical research and pharmaceutical development, particularly in studies related to bone metabolism, calcium regulation, and cancer biology. It serves as a critical research-grade biochemical tool for academic institutions, biotechnology firms, and pharmaceutical companies engaged in peptide-based drug discovery and signaling pathway analysis.

Application

• Biomedical Research: Used as a reference standard and active agent in studies of parathyroid hormone (PTH) and PTHrP receptor interactions and signaling cascades.
• Drug Discovery: Serves as a lead compound or a structural template for the development of novel therapeutics targeting bone disorders such as osteoporosis and hypercalcemia of malignancy.
• In Vitro & In Vivo Studies: Applied in cell-based assays and animal models to investigate the physiological and pathological roles of PTHrP in skeletal development and cancer progression.
• Biochemical Reagent: Utilized in enzymatic studies, protein-protein interaction assays, and as a calibrant in analytical method development (e.g., HPLC, MS).
• Antibody Production: Can be used as an immunogen for generating specific antibodies for diagnostic or research immunoassays.

Basic Information

Product Name	H-Tyr-Pro-Ile-Lys-Pro-Glu-Ala-Pro-Gly-Glu-Asp-Ala-Ser-Pro-Glu-Glu-Leu-Asn-Arg-Tyr-Tyr-Ala-Ser-Leu-Arg-His-Tyr-Leu-Asn-Leu-Val-Thr-Arg-Pro-Arg-Tyr-Nh2
CAS No.	179986-93-7
Molecular Formula	C185H294N58O55
Molecular Weight	4088.7 g/mol
Synonyms	PTHrP (1-34) amide, human; Parathyroid Hormone-Related Protein (1-34) amide; hPTHrP(1-34)NH2; PTHLH (1-34); Tyr-Pro-Ile-Lys-Pro-Glu-Ala-Pro-Gly-Glu-Asp-Ala-Ser-Pro-Glu-Glu-Leu-Asn-Arg-Tyr-Tyr-Ala-Ser-Leu-Arg-His-Tyr-Leu-Asn-Leu-Val-Thr-Arg-Pro-Arg-Tyr-NH2; ALX-550-110; Osteostatin precursor fragment
EINECS	Contact for details

Quality Control

Our research-grade peptides are manufactured under controlled conditions and undergo rigorous analytical testing to ensure identity, purity, and consistency. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity by HPLC, molecular weight confirmation by mass spectrometry, and other relevant analytical data. We adhere to stringent quality management practices to support the reliability required for critical research applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term storage, keep the lyophilized powder at -20°C or below. This product is hygroscopic (moisture-sensitive). Solutions should be prepared in appropriate buffers and used immediately or aliquoted and stored at ≤ -20°C to minimize degradation. Avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Molecular Weight	4088.7 ± 2.0 Da (by MS)
Solubility	Soluble in water or dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.