Description

4-Chloro-6-Acetoxy-7-Methoxyquinazoline Hydrochloride is a high-purity, functionalized quinazoline derivative of significant interest in advanced organic synthesis. This compound serves as a critical pharmaceutical intermediate and building block for the development of targeted therapeutic agents. It is primarily required by research institutions and manufacturers in the pharmaceutical and fine chemical sectors for the synthesis of novel drug candidates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of tyrosine kinase inhibitors and other small-molecule drug candidates targeting various disease pathways.
• Chemical Research & Development: Used as a versatile scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Active Pharmaceutical Ingredient (API) Synthesis: Employed in multi-step synthetic routes for the production of complex, high-value active pharmaceutical ingredients.
• Biochemical Probe Development: Serves as a starting material for creating labeled compounds or probes used in biological assays and diagnostic research.
• Fine Chemical Manufacturing: Utilized in the custom synthesis of specialty chemicals for advanced material science and agrochemical applications.

Basic Information

Product Name	4-Chloro-6-Acetoxy-7-Methoxyquinazoline Hydrochloride
CAS No.	179688-54-1
Molecular Formula	C₁₁H₁₀ClN₂O₃·HCl
Molecular Weight	301.57 g/mol
Synonyms	4-Chloro-6-acetoxy-7-methoxyquinazoline HCl; 7-Methoxy-6-acetoxy-4-chloroquinazoline hydrochloride; 4-Chloro-7-methoxy-6-quinazolinyl acetate hydrochloride; 6-Acetoxy-4-chloro-7-methoxyquinazoline hydrochloride; Quinazoline, 4-chloro-6-(acetyloxy)-7-methoxy-, hydrochloride (1:1)
EINECS	Contact for details

Quality Control

Our 4-Chloro-6-Acetoxy-7-Methoxyquinazoline Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing purity, impurities, and other critical parameters are provided to guarantee batch-to-batch consistency and support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.