Description

4-(3-Fluoro-5-Hydroxyphenyl)-3,4,5,6-Tetrahydro-2H-Pyran-4-Carboxylate Ethyl is a high-purity fluorinated heterocyclic building block of significant interest in advanced organic synthesis. This compound is valued for its unique molecular architecture, which incorporates both a fluorinated phenol and a tetrahydropyran carboxylate ester, making it a versatile intermediate for constructing complex pharmacophores. It is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used as a building block for creating advanced herbicides and fungicides, leveraging the bioactivity of the fluorinated aromatic system.
• Material Science Research: Serves as a precursor for specialty monomers or ligands in the development of advanced polymers and functional materials.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes for studying enzyme activity and biological pathways due to its modifiable functional groups.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects requiring high-purity fluorinated intermediates.

Basic Information

Product Name	4-(3-Fluoro-5-Hydroxyphenyl)-3,4,5,6-Tetrahydro-2H-Pyran-4-Carboxylate Ethyl
CAS No.	179420-67-8
Molecular Formula	C14H15FO4
Molecular Weight	266.26 g/mol
Synonyms	Ethyl 4-(3-fluoro-5-hydroxyphenyl)-3,4,5,6-tetrahydro-2H-pyran-4-carboxylate; 4-(3-Fluoro-5-hydroxyphenyl)tetrahydro-2H-pyran-4-carboxylic acid ethyl ester; 3-Fluoro-5-[(4-ethoxycarbonyl)tetrahydropyran-4-yl]phenol; 179420-67-8; Ethyl 4-(3-fluoro-5-hydroxyphenyl)oxane-4-carboxylate; 4-Carbethoxy-4-(3-fluoro-5-hydroxyphenyl)tetrahydropyran
EINECS	Contact for details

Quality Control

Our 4-(3-Fluoro-5-Hydroxyphenyl)-3,4,5,6-Tetrahydro-2H-Pyran-4-Carboxylate Ethyl is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications in GMP (Good Manufacturing Practice) environments for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents. The container must be kept tightly sealed to protect the contents from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.