Description

(2R)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}(Methyl)Amino)-3-(Naphthalen-2-Yl)Propanoic Acid is a sophisticated, non-natural amino acid derivative featuring a Fmoc-protected N-methylated backbone and a naphthyl side chain. This compound matters as a critical high-purity building block for the synthesis of complex peptides and peptidomimetics, enabling researchers to modulate peptide conformation, stability, and receptor interaction. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing novel therapeutic agents, particularly in oncology and metabolic disease research.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated synthesis of complex peptide sequences.
• Peptidomimetic Drug Discovery: Used to introduce a rigid, hydrophobic naphthyl group and N-methylation to enhance metabolic stability and membrane permeability of lead compounds.
• Chemical Biology Probes: Incorporation into peptides to study protein-protein interactions and enzyme specificity.
• API Intermediate Manufacturing: Serves as a chiral intermediate in the multi-step synthesis of potential Active Pharmaceutical Ingredients (APIs).
• Academic Research: Utilized in universities and research institutes for studying peptide structure-activity relationships (SAR).
• Custom Synthesis Services: A starting material for contract research organizations (CROs) and CDMOs offering bespoke peptide synthesis.

Basic Information

Product Name	(2R)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}(Methyl)Amino)-3-(Naphthalen-2-Yl)Propanoic Acid
CAS No.	179385-30-9
Molecular Formula	C30H25NO4
Molecular Weight	463.52 g/mol
Synonyms	Fmoc-N-Me-2-Nal-OH; Fmoc-N-methyl-2-naphthylalanine; (2R)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl(methyl)amino]-3-(naphthalen-2-yl)propanoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-2-naphthylalanine; Fmoc-N-Me-2-Nal; Nα-Fmoc-Nα-methyl-2-naphthylalanine; N-Fmoc-N-methyl-2-naphthylalanine; L-Fmoc-N-Me-2-Nal-OH
EINECS	Contact for details

Quality Control

Our (2R)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}(Methyl)Amino)-3-(Naphthalen-2-Yl)Propanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and chiral integrity meet the stringent requirements for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing purity, specific rotation, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This product is hygroscopic (moisture-sensitive); ensure the container is sealed under inert atmosphere after each use to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.