Description

Boc-D-Dap(Alloc)-Oh is a protected, non-proteinogenic amino acid derivative widely used in advanced peptide synthesis. This compound is essential for introducing the diaminopropionic acid (Dap) moiety with orthogonal protecting groups, enabling precise control over complex peptide chain assembly. It is a critical building block for researchers and manufacturers in pharmaceutical development, particularly for creating novel therapeutic peptides and peptidomimetics with enhanced stability and bioactivity.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled incorporation of D-diaminopropionic acid residues into peptide sequences.
• Pharmaceutical Research: Used in the development of peptide-based drugs, including antimicrobial peptides, hormone analogs, and targeted therapeutics.
• Peptidomimetic Design: Serves as a scaffold for creating modified peptides with improved metabolic stability and receptor selectivity.
• Bioconjugation: The Alloc (Allyloxycarbonyl) protecting group allows for selective deprotection under mild conditions, facilitating site-specific labeling or conjugation.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to discover new bioactive compounds.
• Academic & Institutional Research: A fundamental reagent for studying peptide structure-activity relationships and synthetic methodology.

Basic Information

Product Name	Boc-D-Dap(Alloc)-Oh
CAS No.	179251-60-6
Molecular Formula	C₁₂H₂₀N₂O₆
Molecular Weight	288.30 g/mol
Synonyms	(2R)-3-{[(Allyloxy)carbonyl]amino}-2-{[(tert-butoxy)carbonyl]amino}propanoic acid; Boc-D-Dap(Alloc)-OH; D-Diaminopropionic Acid, Nα-Boc-Nβ-Alloc-; Nα-(tert-Butoxycarbonyl)-Nβ-(allyloxycarbonyl)-D-diaminopropionic acid; Boc-D-2,3-diaminopropionic acid(Alloc)-OH; tert-Butyl ((R)-1-(((allyloxy)carbonyl)amino)-3-carboxypropan-2-yl)carbamate; Boc-D-Dap(Alloc)
EINECS	Contact for details

Quality Control

Every batch of Boc-D-Dap(Alloc)-Oh is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We ensure compliance with high-purity standards suitable for research and pharmaceutical applications. A detailed Certificate of Analysis (COA) providing purity, chiral purity, and impurity profiles is supplied with each shipment to guarantee consistent quality and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.