Description

2(1H)-Pyrimidinone, 4-Amino-1-(Tetrahydro-3,4-Dihydroxy-2-Furanyl)-, [2S-(2Alpha,3Ba,4Ba)]- (9Ci) is a high-purity, stereochemically defined nucleoside analog with significant synthetic utility. This compound is valued for its role as a key chiral building block in the synthesis of complex pharmaceutical intermediates and active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and manufacturers in the pharmaceutical and biotechnology sectors engaged in nucleoside chemistry, antiviral drug development, and medicinal chemistry research. The product is supplied with full analytical documentation to ensure traceability and support critical R&D and cGMP manufacturing processes.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel nucleoside-based antiviral and anticancer agents.
• Medicinal Chemistry Research: Used as a chiral scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Biochemical Tool Compound: Employed in enzymatic studies and as a substrate analog to investigate metabolic pathways.
• Process Chemistry Development: Utilized in route scouting and scale-up optimization for the production of complex active pharmaceutical ingredients (APIs).
• Academic Research: A valuable reagent for universities and research institutes focusing on organic synthesis, carbohydrate chemistry, and heterocyclic compound development.

Basic Information

Item	Details
Product Name	2(1H)-Pyrimidinone, 4-Amino-1-(Tetrahydro-3,4-Dihydroxy-2-Furanyl)-, [2S-(2Alpha,3Ba,4Ba)]- (9Ci)
CAS No.	179239-88-4
Molecular Formula	C8H11N3O4
Molecular Weight	213.19 g/mol
Synonyms	4-Amino-1-((2S,3R,4R)-3,4-dihydroxytetrahydrofuran-2-yl)pyrimidin-2(1H)-one; (2S,3R,4R)-2-(4-Amino-2-oxopyrimidin-1(2H)-yl)tetrahydrofuran-3,4-diol; 4-Amino-1-((2S,3R,4R)-3,4-dihydroxytetrahydrofuran-2-yl)-1,2-dihydropyrimidin-2-one; A Chiral Nucleoside Analog; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our 2(1H)-Pyrimidinone, 4-Amino-1-(Tetrahydro-3,4-Dihydroxy-2-Furanyl)-, [2S-(2Alpha,3Ba,4Ba)]- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity, NMR for structural confirmation, and residual solvent analysis to ensure it meets stringent specifications for research and development use. Certificates of Analysis (COA) with complete batch traceability are provided and can be tailored to support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); therefore, the container should be kept tightly sealed in a dry environment. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.