Description

tert-Butyloxycarbonyl-Tyrosyl-Prolyl-Glycyl-Phenylalanyl-Leucyl-(o-tert-Butyl)Threonine is a protected hexapeptide sequence, a key building block in advanced solid-phase peptide synthesis (SPPS). This compound is essential for researchers and manufacturers requiring high-purity, custom peptide fragments for pharmaceutical development and biochemical research. It is primarily utilized by the biotechnology and pharmaceutical industries for the creation of novel therapeutic peptides, diagnostic agents, and biochemical probes.

Application

• Pharmaceutical Intermediates: Critical building block for the synthesis of complex therapeutic peptides targeting metabolic disorders, oncology, and cardiovascular diseases.
• Biochemical Research: Used in structure-activity relationship (SAR) studies to investigate peptide-receptor interactions and optimize biological activity.
• Custom Peptide Synthesis: Serves as a key fragment for contract research organizations (CROs) and CDMOs producing bespoke peptides for client projects.
• API Development: Intermediate in the research and development of new Active Pharmaceutical Ingredients (APIs) following cGMP guidelines.
• Diagnostic Reagent Production: Component in the manufacture of peptide-based diagnostic kits and labeled probes for immunoassays.

Basic Information

Product Name	tert-Butyloxycarbonyl-Tyrosyl-Prolyl-Glycyl-Phenylalanyl-Leucyl-(o-tert-Butyl)Threonine
CAS No.	179124-36-8
Molecular Formula	C50H74N6O12
Molecular Weight	951.16 g/mol
Synonyms	Boc-Tyr-Pro-Gly-Phe-Leu-Thr(O-tBu)-OH; Boc-Tyr-Pro-Gly-Phe-Leu-Thr(tBu)-OH; Boc-Tyr-Pro-Gly-Phe-Leu-Thr(O-tert-butyl)-OH; Hexapeptide Boc-Tyr-Pro-Gly-Phe-Leu-Thr(O-tBu); N-α-Boc-O-tert-butyl-L-threonyl-L-leucyl-L-phenylalanyl-glycyl-L-prolyl-L-tyrosine; (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2S)-2-[(2-Methylpropan-2-yl)oxycarbonylamino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidin-2-yl]formamido]acetamido]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-3-[(2-methylpropan-2-yl)oxy]butanoic acid
EINECS	Contact for details

Quality Control

Our peptide building blocks are produced under strict quality management systems. Each batch of tert-Butyloxycarbonyl-Tyrosyl-Prolyl-Glycyl-Phenylalanyl-Leucyl-(o-tert-Butyl)Threonine undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and chiral analysis to ensure stereochemical integrity. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee compliance with your research or cGMP-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -10°C. This material is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Assay (HPLC)	≥ 97.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.