Description

D-Proline, 4-Hydroxy-, Methyl Ester, (4S)- (9Ci) is a high-purity, non-proteinogenic amino acid derivative, specifically the methyl ester of 4-hydroxy-D-proline. This compound is a valuable chiral building block and intermediate in advanced organic synthesis, prized for its defined stereochemistry and functional groups. It is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries, particularly for the development of peptidomimetics, active pharmaceutical ingredients (APIs), and complex bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, especially protease inhibitors and other therapeutic peptides.
• Peptidomimetic Research: Used to construct conformationally constrained peptide analogs to study structure-activity relationships and improve metabolic stability.
• Asymmetric Synthesis: Serves as a chiral auxiliary or starting material in stereoselective chemical reactions to introduce specific stereocenters.
• Bioconjugation & Probe Development: Utilized in the design and synthesis of labeled compounds for biochemical and diagnostic applications.
• Fine Chemical Production: An intermediate in the multi-step synthesis of complex, high-value specialty chemicals and catalysts.

Basic Information

Product Name	D-Proline, 4-Hydroxy-, Methyl Ester, (4S)- (9Ci)
CAS No.	178962-09-9
Molecular Formula	C6H11NO3
Molecular Weight	145.16 g/mol
Synonyms	(4S)-4-Hydroxy-D-proline methyl ester; Methyl (4S)-4-hydroxy-D-prolinate; Methyl (2S,4S)-4-hydroxypyrrolidine-2-carboxylate; 4-Hydroxy-D-proline methyl ester; D-4-Hydroxyproline methyl ester; (4R)-4-Hydroxy-L-proline methyl ester (enantiomer); Hydroxyproline methyl ester
EINECS	Contact for details

Quality Control

Our D-Proline, 4-Hydroxy-, Methyl Ester, (4S)- (9Ci) is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and synthesis. A detailed Certificate of Analysis (COA) providing identity, purity, and impurity profiles is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.