Description

Fmoc-D-Dap(Aloc)-OH is a protected, non-proteinogenic amino acid derivative specifically engineered for advanced solid-phase peptide synthesis (SPPS). This compound is critical for researchers and manufacturers requiring precise control over side-chain functionality and stereochemistry during the construction of complex peptides. It is an essential building block for the pharmaceutical and biotechnology industries, particularly in the development of novel therapeutic peptides, peptidomimetics, and biochemical probes where the orthogonal protection of the diaminopropionic acid side chain is required.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid building block for the automated synthesis of complex peptides with specific side-chain modifications.
• Pharmaceutical Research: Used in the discovery and development of novel peptide-based therapeutics, including antimicrobial peptides, hormone analogs, and targeted drug conjugates.
• Peptidomimetic Design: Enables the incorporation of a D-configured diaminopropionic acid residue with orthogonal Aloc protection, allowing for selective deprotection and further functionalization in drug design.
• Bioconjugation and Probe Synthesis: Serves as a precursor for creating labeled peptides or peptide-biomolecule conjugates for diagnostic and research applications.
• Combinatorial Chemistry Libraries: A valuable component for generating diverse libraries of peptide-like compounds for high-throughput screening.

Basic Information

Product Name	Fmoc-D-Dap(Aloc)-OH
CAS No.	178924-05-5
Molecular Formula	C22H22N2O6
Molecular Weight	410.42 g/mol
Synonyms	Fmoc-D-2,3-diaminopropionic acid(Aloc)-OH; Nα-Fmoc-Nβ-Allyloxycarbonyl-D-2,3-diaminopropionic acid; Fmoc-D-Dap(Alloc)-OH; (R)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(((allyloxy)carbonyl)amino)propanoic acid; Fmoc-D-β-diaminopropionic acid(Aloc); Nα-Fmoc-Nβ-Alloc-D-diaminopropionic acid; Fmoc-D-Dap(Aloc)
EINECS	Contact for details

Quality Control

Our Fmoc-D-Dap(Aloc)-OH is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive research and production applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. We adhere to relevant industry standards for fine chemical and pharmaceutical intermediate production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% D-isomer
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.