Description

6-(Trifluoromethyl)-5-Methoxyindoline is a high-value, multi-functional indoline derivative featuring a trifluoromethyl group and a methoxy substituent. This compound serves as a critical advanced pharmaceutical intermediate (API) and a versatile building block for the synthesis of complex organic molecules. It is essential for research and development chemists and manufacturers in the pharmaceutical, agrochemical, and material science industries seeking to incorporate fluorine-containing motifs into their target compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science Building Block: Employed in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Organic Synthesis Reagent: Acts as a versatile scaffold for constructing complex heterocyclic compounds in medicinal chemistry.
• Fluorine Chemistry Research: A valuable compound for studying the effects of fluorine substitution on molecular properties and reactivity.
• Contract Manufacturing & Development: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	6-(Trifluoromethyl)-5-Methoxyindoline
CAS No.	178896-79-2
Molecular Formula	C10H10F3NO
Molecular Weight	217.19 g/mol
Synonyms	5-Methoxy-6-(trifluoromethyl)indoline; 5-Methoxy-6-(trifluoromethyl)-2,3-dihydro-1H-indole; 1H-Indole, 2,3-dihydro-5-methoxy-6-(trifluoromethyl)-; 6-Trifluoromethyl-5-methoxyindoline; 5-Methoxy-6-trifluoromethylindoline; Indoline, 6-(trifluoromethyl)-5-methoxy-
EINECS	Contact for details

Quality Control

Our 6-(Trifluoromethyl)-5-Methoxyindoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high purity and batch-to-batch consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.