Description

(D-Trp32)-Neuropeptide Y (Human, Rat) CAS NO 178861-83-1 is a synthetic, site-specifically modified analog of the endogenous neuropeptide Y (NPY), a critical neuromodulator involved in numerous physiological processes. This compound matters for advanced research as the D-tryptophan substitution at position 32 confers enhanced metabolic stability and altered receptor binding affinity, making it a vital tool for dissecting NPY signaling pathways. It is primarily needed by pharmaceutical R&D teams and academic researchers focused on neuroscience, metabolic disorders, and cardiovascular function.

Application

• Neuroscience Research: Used as a stable analog to study the role of Neuropeptide Y in appetite regulation, anxiety, stress response, and circadian rhythms.
• Receptor Binding Studies: Essential for in vitro and in vivo assays to characterize the binding affinity and selectivity of NPY receptor subtypes (Y1, Y2, Y4, Y5, y6).
• Metabolic Disorder Research: Investigates the complex effects of NPY on energy homeostasis, adiposity, and insulin secretion for potential therapeutic development.
• Cardiovascular Research: Applied in studies exploring NPY's role in blood pressure regulation, vascular tone, and angiogenesis.
• Structure-Activity Relationship (SAR) Studies: Serves as a key reference compound for designing and testing novel NPY analogs with improved pharmacological profiles.
• Biochemical Standard: Used as a calibrated standard in mass spectrometry, HPLC, and other analytical techniques for quantifying NPY levels in biological samples.

Basic Information

Product Name	(D-Trp32)-Neuropeptide Y (Human, Rat)
CAS No.	178861-83-1
Molecular Formula	C190H287N55O57S
Molecular Weight	4253.7 g/mol
Synonyms	[D-Tryptophan32]-Neuropeptide Y; NPY (22-36), D-Trp32-; [D-Trp32]NPY; Neuropeptide Y (human, rat) (D-Trp32)-; D-Trp32-Neuropeptide Y; NPY analog (D-Trp32); Tyr-Pro-Ser-Lys-Pro-Asp-Asn-Pro-Gly-Glu-Asp-Ala-Pro-Ala-Glu-Asp-Leu-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu-D-Trp-Thr-Arg-Gln-Arg-Tyr-NH2 (Disulfide bridge: Cys7-Cys17)
EINECS	Contact for details

Quality Control

Our (D-Trp32)-Neuropeptide Y (Human, Rat) is manufactured under stringent conditions to ensure the highest standards of purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity verification and mass spectrometry for identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to store desiccated under inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Mass Spectrometry (ESI-TOF)	Conforms to theoretical mass

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.