Description

L-Proline, 5-(2-Hydroxyethyl)-, cis- (9Ci) is a specialized, non-proteinogenic proline derivative characterized by a cis-configuration and a 2-hydroxyethyl side chain at the 5-position. This unique molecular structure makes it a valuable chiral building block and intermediate for advanced organic synthesis and pharmaceutical research. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for applications requiring high stereochemical purity and functional group diversity.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for peptidomimetics and conformationally constrained analogs.
• Agrochemical Synthesis: Used in the design and synthesis of advanced herbicides, fungicides, and plant growth regulators that benefit from its proline-based scaffold.
• Biochemical Research: Acts as a substrate or inhibitor in enzymatic studies and as a component in the synthesis of custom peptides for probing biological pathways.
• Catalyst & Ligand Development: Employed as a precursor for creating novel chiral catalysts and ligands used in asymmetric synthesis to induce high enantioselectivity.
• Fine Chemical Production: Functions as a building block for the manufacture of specialty chemicals, flavors, and fragrances requiring specific stereochemistry.
• Material Science: Investigated for incorporation into polymers and smart materials where its hydroxy group enables further functionalization.

Basic Information

Product Name	L-Proline, 5-(2-Hydroxyethyl)-, cis- (9Ci)
CAS No.	178813-39-3
Molecular Formula	C7H13NO3
Molecular Weight	159.18 g/mol
Synonyms	cis-5-(2-Hydroxyethyl)-L-proline; (2S,5S)-5-(2-Hydroxyethyl)proline; L-4-Hydroxy-2-pyrrolidinepropanoic acid, cis-; (2S,5S)-2-Carboxy-5-(2-hydroxyethyl)pyrrolidine; 5-(2-Hydroxyethyl)-L-proline, cis-; L-Proline, 5-(2-hydroxyethyl)-, (cis)-; 178813-39-3; cis-Hydroxyethylproline
EINECS	Contact for details

Quality Control

Our L-Proline, 5-(2-Hydroxyethyl)-, cis- (9Ci) is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed to prevent absorption of moisture from the atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee (cis-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.