Description

n-α-Fmoc-L-Asparagine n-Carboxyanhydride is a highly specialized, protected amino acid derivative used as a critical building block in solid-phase peptide synthesis (SPPS). Its value lies in enabling the controlled, racemization-free incorporation of L-asparagine into complex peptide sequences, which is essential for producing high-purity peptides for research and therapeutic applications. This compound is primarily needed by pharmaceutical R&D teams, biotechnology companies, and academic research laboratories focused on developing novel peptide-based drugs, diagnostics, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key monomer for the automated, sequential assembly of peptides, particularly those containing the asparagine residue.
• Pharmaceutical Intermediate: Used in the research and development of therapeutic peptides, including hormone analogs, antimicrobial peptides, and targeted drug conjugates.
• Bioconjugation & Labeling: Serves as a precursor for introducing asparagine sites specifically designed for subsequent chemical modification or fluorescent labeling.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to discover new bioactive peptide leads.
• Academic & Biochemical Research: Essential for studying protein-protein interactions, enzyme substrates, and receptor ligands by constructing custom peptide sequences.
• Production of Protected Peptide Fragments: Used in solution-phase synthesis for creating specific, protected segments of larger peptides or proteins.

Basic Information

Product Name	n-α-Fmoc-L-Asparagine n-Carboxyanhydride
CAS No.	178614-75-0
Molecular Formula	C20H16N2O6
Molecular Weight	380.35 g/mol
Synonyms	Fmoc-Asn-NCA; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-asparagine N-carboxyanhydride; (4S)-4-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-2,5-dioxo-1,3-oxazolidine-4-carboxamide; Fmoc-L-asparagine NCA; Nα-Fmoc-L-asparagine N-carboxyanhydride; NCA-Fmoc-Asn-OH; Fmoc-Asn-N-carboxy anhydride; Fmoc-protected asparagine NCA
EINECS	Contact for details

Quality Control

Our n-α-Fmoc-L-Asparagine n-Carboxyanhydride is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, critical for sensitive peptide synthesis applications. Each lot undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to meet exacting research and development standards. A comprehensive Certificate of Analysis (COA) detailing identity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a desiccated environment due to its hygroscopic and moisture-sensitive nature. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	[α]²⁰D: -15.0° to -25.0° (c=1 in DMF)
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMF, DMSO; sparingly soluble in THF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.