Description

Fmoc-D-Tyr(Po3H2)-Oh is a protected, phosphorylated derivative of D-tyrosine, specifically designed for solid-phase peptide synthesis (SPPS). This compound is critical for the site-specific incorporation of phosphotyrosine, a key post-translational modification, into synthetic peptides. It is an essential building block for researchers and manufacturers in pharmaceutical development, biochemical research, and proteomics who require high-purity, sequence-defined peptides to study signaling pathways and develop targeted therapies.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it is a fundamental building block for the automated synthesis of phosphopeptides.
• Phosphopeptide Synthesis: Specifically used to incorporate phosphotyrosine residues, mimicking a vital post-translational modification involved in cell signaling.
• Biochemical Research: Synthesis of substrates and inhibitors for kinase and phosphatase enzyme studies.
• Pharmaceutical R&D: Development of peptide-based drug candidates targeting phosphotyrosine-dependent protein-protein interactions.
• Antibody Production: Creation of phospho-specific epitopes for generating and screening monoclonal antibodies.
• Diagnostic Reagent Development: Used in the manufacture of peptides for diagnostic assays and biosensors.
• Chemical Biology Probes: Synthesis of tagged phosphopeptides for pull-down assays and cellular pathway analysis.

Basic Information

Product Name	Fmoc-D-Tyr(Po3H2)-Oh
CAS No.	178432-30-9
Molecular Formula	C₂₄H₂₂NO₉P
Molecular Weight	499.41 g/mol
Synonyms	Fmoc-D-phosphotyrosine; Fmoc-O-phosphono-D-tyrosine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-phosphono-D-tyrosine; Fmoc-D-Tyr(PO₃H₂)-OH; Fmoc-D-Tyr(P)-OH; (2R)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-(4-phosphonoxyphenyl)propanoic acid; N-Fmoc-O-phosphono-D-tyrosine; Fmoc-D-Tyr[PO(OH)₂]-OH
EINECS	Contact for details

Quality Control

Our Fmoc-D-Tyr(Po3H2)-Oh is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research and development applications. Each lot undergoes comprehensive analytical testing including HPLC for purity and NMR for structural confirmation. Certificates of Analysis (COA) detailing specific results for identity, assay, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.