Description

Nociceptin (1-7) CAS NO 178249-42-8 is a bioactive heptapeptide fragment derived from the endogenous neuropeptide nociceptin/orphanin FQ (N/OFQ), which acts as a ligand for the NOP (nociceptin opioid peptide) receptor. This compound is a critical research tool for investigating the complex N/OFQ-NOP receptor system, which plays a significant role in modulating pain, anxiety, stress, and reward pathways. It is primarily utilized by pharmaceutical R&D teams, academic neuroscientists, and biochemical researchers focused on central nervous system (CNS) drug discovery and neuropharmacology studies.

Application

• Neuroscience Research: Used as a reference standard and active agent in studies exploring pain modulation, anxiety, depression, and stress responses.
• Pharmacological Assays: Serves as a key ligand in receptor binding and functional assays (e.g., cAMP inhibition, GTPγS binding) to characterize NOP receptor activity and screen novel compounds.
• Drug Discovery & Development: A vital intermediate and tool peptide for developing novel analgesics and CNS-targeting therapeutics with potentially fewer side effects than classical opioids.
• Biochemical Studies: Employed to study signal transduction pathways and the physiological roles of the nociceptin system in various animal models.
• Academic & Institutional Research: Supports fundamental research in universities and institutes focused on peptide chemistry, neurobiology, and behavioral pharmacology.

Basic Information

Product Name	Nociceptin (1-7)
CAS No.	178249-42-8
Molecular Formula	C38H55N9O9
Molecular Weight	781.91 g/mol
Synonyms	Nociceptin (1-7) amide; N/OFQ(1-7); Orphanin FQ (1-7); Phe-Gly-Gly-Phe-Thr-Gly-Ala-amide; [Phe¹, Gly², Gly³, Phe⁴, Thr⁵, Gly⁶, Ala⁷]-Nociceptin amide; NOP receptor agonist fragment; Nociceptin heptapeptide
EINECS	Contact for details

Quality Control

Our Nociceptin (1-7) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and mass spectrometry (MS) for identity confirmation. We provide full traceability and Certificates of Analysis (COA) are available upon request, detailing purity, peptide content, and solvent residues to support your research and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.