Description

Orphanin Fq (1-11) is a synthetic peptide fragment corresponding to the N-terminal sequence of the endogenous neuropeptide, Nociceptin/Orphanin FQ. This compound is a critical research tool for investigating the NOP (Nociceptin Opioid Peptide) receptor system, which plays a significant role in modulating pain, anxiety, and reward pathways. It is primarily utilized by pharmaceutical researchers, neuroscientists, and academic institutions engaged in neuropharmacology and central nervous system drug discovery.

Application

• Neuroscience Research: Fundamental studies on the NOP receptor's role in pain modulation, stress response, and emotional behavior.
• Pharmacological Assay Development: Used as a reference standard or ligand in receptor binding and functional assays (e.g., cAMP, calcium mobilization) to screen novel NOP receptor agonists or antagonists.
• Structure-Activity Relationship (SAR) Studies: Serves as a core scaffold for designing and synthesizing modified peptide analogs to explore receptor interaction sites.
• In Vivo Behavioral Studies: Administration in animal models to study effects on nociception, anxiety, learning, and memory.
• Biochemical Research: Investigation of peptide processing, degradation, and signal transduction mechanisms downstream of NOP receptor activation.
• Diagnostic Tool Development: Potential use in developing assays to study N/OFQ peptide levels in biological samples.

Basic Information

Product Name	Orphanin Fq (1-11)
CAS No.	178249-41-7
Molecular Formula	C60H89N17O13
Molecular Weight	1248.5 g/mol
Synonyms	Nociceptin (1-11); Orphanin FQ (1-11); N/OFQ(1-11); Phe-Gly-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-NH2; FGGFTGARKSA-NH2; NOP receptor agonist fragment
EINECS	Contact for details

Quality Control

Our Orphanin Fq (1-11) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, keep under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC-MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Single Impurity (HPLC)	≤ 1.0%
Amino Acid Composition	± 10% of theoretical
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.