Description

N1,N8-Diacetylspermidine (Hydrochloride) is a chemically modified derivative of the naturally occurring polyamine spermidine, supplied as its hydrochloride salt for enhanced stability and handling. This specialized biochemical is a critical intermediate and research tool for studying polyamine metabolism, cellular signaling, and post-translational modification processes. It is primarily utilized by researchers and developers in the life sciences, pharmaceutical R&D, and biotechnology sectors for applications ranging from basic biochemical research to the development of novel therapeutic agents.

Application

• Biochemical Research: Serves as a key substrate or inhibitor in enzymatic studies related to polyamine acetylation and deacetylation pathways.
• Pharmaceutical Development: Used as a high-purity reference standard or intermediate in the synthesis of potential drug candidates targeting polyamine metabolism.
• Cell Biology Studies: Employed to investigate the role of acetylated polyamines in cellular processes such as proliferation, apoptosis, and autophagy.
• Diagnostic Reagent Manufacturing: Acts as a raw material in the production of specialized assay kits and reagents for research and clinical diagnostics.
• Metabolomics & Proteomics: Utilized as a standard for the identification and quantification of acetylated polyamines in complex biological samples via LC-MS or HPLC.
• Enzyme Characterization: Essential for the functional analysis and kinetic studies of spermidine/spermine N1-acetyltransferase (SSAT) and other related enzymes.

Basic Information

Product Name	N1,N8-Diacetylspermidine (Hydrochloride)
CAS No.	178244-42-3
Molecular Formula	C11H24N3O2 • HCl
Molecular Weight	263.79 g/mol (Free base: 227.33 g/mol)
Synonyms	N1,N8-Diacetylspermidine HCl; N1,N8-Diacetylspermidine hydrochloride; Diacetylspermidine hydrochloride; Spermidine, N1,N8-diacetyl-, hydrochloride; 1,8-Diacetylspermidine HCl; N1-Acetyl-N8-acetylspermidine hydrochloride; Bis(acetylspermidine) hydrochloride
EINECS	Contact for details

Quality Control

Our N1,N8-Diacetylspermidine (Hydrochloride) is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical testing, including identity confirmation by spectroscopic methods and purity assessment by chromatographic techniques. A detailed Certificate of Analysis (COA) documenting identity, purity, and other critical parameters is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive). For long-term storage, consider desiccated conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.