Description

7-(3-Aminopyrrolidin-1-Yl)-1-Cyclopropyl-6,8-Difluoro-5-Methyl-4-Oxo-Quinoline-3-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate of significant commercial importance. This compound is a key synthetic precursor in the development of novel fluoroquinolone antibiotics, valued for its precise molecular structure which is critical for achieving targeted biological activity. It is primarily required by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the synthesis of next-generation antibacterial agents.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of advanced fluoroquinolone antibiotic candidates.
• Antibacterial Drug Research: Used in medicinal chemistry for the discovery and development of new antibacterial agents with improved efficacy and spectrum.
• Chemical Synthesis Reference Standard: Serves as a high-purity reference material for analytical method development and quality control in API manufacturing.
• Process Chemistry Development: Employed in scaling up and optimizing synthetic routes for complex active pharmaceutical ingredients (APIs).
• Academic & Contract Research: Utilized in university and CRO laboratories for pharmacological studies and structure-activity relationship (SAR) research.

Basic Information

Product Name	7-(3-Aminopyrrolidin-1-Yl)-1-Cyclopropyl-6,8-Difluoro-5-Methyl-4-Oxo-Quinoline-3-Carboxylic Acid
CAS No.	178233-18-6
Molecular Formula	C18H19F2N3O3
Molecular Weight	363.36 g/mol
Synonyms	7-(3-Aminopyrrolidin-1-yl)-1-cyclopropyl-6,8-difluoro-5-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; 1-Cyclopropyl-6,8-difluoro-5-methyl-7-(3-pyrrolidinylamino)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid; Garenoxacin Intermediate; DW-224a Intermediate; T-3811 Intermediate; 7-(3-Aminopyrrolidin-1-yl)-1-cyclopropyl-6,8-difluoro-5-methyl-4-oxoquinoline-3-carboxylic acid; 178233-18-6
EINECS	Contact for details

Quality Control

Our production of this pharmaceutical intermediate adheres to stringent GMP (Good Manufacturing Practice) guidelines to ensure batch-to-batch consistency and traceability. Quality is verified through comprehensive analytical methods including HPLC for purity and impurity profiling, NMR and IR for structural confirmation, and KF Titration for moisture content. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment. For long-term storage, consider inert gas purging.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.