Description

7-((S)-3-Amino-1-Pyrrolidinyl)-8-Ethoxy-1-Cyclopropyl-6-Fluoro-1,4-Dihydro-4-Oxoquinoline-3-Carboxylic Acid Hydrochloride is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This compound is a key synthetic precursor in the development of novel fluoroquinolone antibiotics, offering a critical building block for drug discovery and manufacturing. It is primarily required by pharmaceutical R&D laboratories, API (Active Pharmaceutical Ingredient) manufacturers, and fine chemical suppliers focused on anti-infective therapies.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of next-generation fluoroquinolone antibacterial agents.
• Active Pharmaceutical Ingredient (API) Development: Used in research and process development for novel antibiotic candidates targeting resistant bacterial strains.
• Chemical Reference Standard: Serves as a high-purity standard for analytical method development, validation, and quality control in pharmaceutical analysis.
• Academic & Contract Research: Employed in medicinal chemistry research to study structure-activity relationships (SAR) and develop new antibacterial compounds.
• Process Chemistry & Scale-Up: Utilized in optimizing synthetic routes and scaling up production for clinical trial material and commercial API batches.

Basic Information

Product Name	7-((S)-3-Amino-1-Pyrrolidinyl)-8-Ethoxy-1-Cyclopropyl-6-Fluoro-1,4-Dihydro-4-Oxoquinoline-3-Carboxylic Acid Hydrochloride
CAS No.	178174-17-9
Molecular Formula	C20H25FN4O4 · HCl
Molecular Weight	456.90 g/mol
Synonyms	7-[(3S)-3-Amino-1-pyrrolidinyl]-8-ethoxy-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid hydrochloride; (S)-7-(3-Aminopyrrolidin-1-yl)-8-ethoxy-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride; Garenoxacin Intermediate; Garenoxacin Hydrochloride Intermediate; T-3811 Intermediate; BMS-284756 Intermediate; OPC-17116 Intermediate
EINECS	Contact for details

Quality Control

Our 7-((S)-3-Amino-1-Pyrrolidinyl)-8-Ethoxy-1-Cyclopropyl-6-Fluoro-1,4-Dihydro-4-Oxoquinoline-3-Carboxylic Acid Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral purity determination, and residual solvent analysis, to ensure it meets the stringent requirements for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing all specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (S-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.