Description

5-Benzyloxy-D-Tryptophan is a protected derivative of the essential amino acid D-tryptophan, featuring a benzyloxy group at the 5-position of the indole ring. This modification is crucial for its role as a key chiral building block and intermediate in advanced pharmaceutical synthesis. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and biotechnology sectors for the development of peptide-based therapeutics and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the synthesis of complex peptide drugs and novel therapeutic compounds.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate a protected tryptophan residue, enabling specific structural and functional properties.
• Biochemical Research: Serves as a standard or reagent in metabolic pathway studies and enzyme-substrate interaction research.
• API Development: Employed in the research and development stages of new Active Pharmaceutical Ingredients, particularly those targeting neurological and hormonal pathways.
• Asymmetric Synthesis: Utilized as a starting material or intermediate in asymmetric catalytic reactions due to its defined stereochemistry.
• Protecting Group Chemistry: The benzyloxy group allows for selective deprotection strategies during multi-step synthetic sequences.

Basic Information

Product Name	5-Benzyloxy-D-Tryptophan
CAS No.	178153-07-6
Molecular Formula	C19H20N2O3
Molecular Weight	324.38 g/mol
Synonyms	D-5-Benzyloxytryptophan; (R)-2-Amino-3-(5-(benzyloxy)-1H-indol-3-yl)propanoic acid; 5-O-Benzyl-D-tryptophan; 5-Benzyloxy-D-Trp; Boc-5-Benzyloxy-D-tryptophan (when protected); Fmoc-5-Benzyloxy-D-tryptophan (when protected); 5-Bzl-D-Trp-OH
EINECS	Contact for details

Quality Control

Our 5-Benzyloxy-D-Tryptophan is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and synthesis. Certificates of Analysis (COA) detailing identity, purity, and specific impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee (D-isomer)
Loss on Drying	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.