Description

Calcicludine I is a high-purity, synthetic peptide compound of significant interest in biochemical and pharmacological research. This product is valued for its specific biological activity, making it a critical tool for studying calcium channel function and related cellular pathways. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies engaged in neuroscience, cardiovascular research, and drug discovery.

Application

• Biochemical Research: Used as a selective and potent inhibitor in studies of L-type calcium channels.
• Neuroscience Studies: A key reagent for investigating calcium signaling in neuronal cells and synaptic transmission.
• Cardiovascular Research: Employed to study the role of calcium channels in cardiac muscle contraction and vascular tone.
• Drug Discovery & Development: Serves as a reference standard and pharmacological tool in screening assays for novel calcium channel modulators.
• Cellular Physiology: Applied in experiments to understand calcium-dependent processes in various cell types.
• Academic Research: Utilized in university and institutional labs for fundamental biological and medical research projects.

Basic Information

Product Name	Calcicludine I
CAS No.	178036-64-1
Molecular Formula	C185H273N55O53S6
Molecular Weight	~4150.8 g/mol
Synonyms	Calcicludine; Calcicludine I (Dendroaspis angusticeps); Dendrotoxin K; DTX K; Toxin FS2; Calcium Channel Blocker Toxin; L-type Calcium Channel Inhibitor; α-Dendrotoxin
EINECS	Contact for details

Quality Control

Our Calcicludine I is produced under stringent conditions to ensure batch-to-batch consistency and high biological activity. Each lot undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry for identity confirmation, and bioactivity assays. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, peptide content, and performance data.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to store the lyophilized powder under desiccant. Avoid repeated freeze-thaw cycles of reconstituted solutions.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Biological Activity (IC50)	Specified per batch on COA
Solubility	Soluble in water or aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.